脑动脉硬化与高血压脑白质疏松分级的相关性研究

The Correlation Study of Cerebral Arteriosclerosis and the Grading of White Matter of Hypertension

目的探讨3.0T高分辨磁共振脑血管造影(magnetic resonance angiography,MRA)对高血压脑白质疏松(LA)分级与脑动脉硬化(arteriosclerosis,AS)分级程度相关性的临床应用价值。方法收集81例高血压患者,行常规头颅MRI、MRA检查,LA分级与AS分级程度相关性经Spearman分析。结果 81例高血压患者,其中LA的0-3级的的患者分别为19、23、19和20例;MRA显示81例162侧脑血管中,AS正常、轻度、中度、重度分别33.3%(54/162)、25.9%(42/162)、21.0%(34/162)和19.8%(32/162)。LA分级与不同程度AS经Spearman相关系数检验两者成正相关,相关性具有明显统计学意义(r=0.551, P<0.001)。结论 MRI能够清楚显示高血压LA病变范围,MRA可以评估AS程度、了解脑血管损害情况,AS程度越重,高血压LA等级越高。

Objective To explore clinical application value of 3.0 t high resolution magnetic resonance angiography(MRA) on the correlation between hypertension cerebral leukosis(LA) grading and cerebral arteriosclerosis(AS). Methods 81 patients with hypertension were examined by routine skull MRI, MRA. The correlation between LA grade and AS grade was analyzed by spearman. Results Among the 81 patients with high blood pressure, the patients with the 0-3 levels of LA were 19, 23, 19 and 20, respectively. The MRA showed that 81 cases of 162 cerebral vessels, AS manifested as normal, mild, moderate, and severe were 33.3%(54/162), 25.9%(42/162), 21.0%(34/162) and 19.8%(32/162), respectively. The distribution of AS in LA grading was examined by Spearman correlation coefficient, and the two were positively correlated, and the correlation was statistically significant(r=0.551, P<0.001). Conclusion MRI can clearly show the range of hypertensive LA lesion. MRA can assess the extent of the AS, understand the cerebrovascular damage. The higher the degree of AS, the higher the level of the hypertension LA.