摘要
It shows that detrimental exposures and conditions in mothers can lead to the development of obesity and type 2 diabetes in offspring.This can lead to a vicious cycle of metabolic dysfunction,where rising rates of obesity,pre-diabetes,and diabetes in individuals of reproductive age,propagating risks to subsequent generations.It is well established that regular exercise has important health benefits for people with obesity and type 2 diabetes.Recently,increasing studies aim to examine the effects of maternal exercise on metabolic health in offspring.This review aims to demonstrate the evidence linking maternal exercise during critical periods of development and its implications for glucose metabolism in offspring,including intervention timing,sexual dimorphism,different exercise type,and intensity.Then we further examine the potential role of epigenetic modifications in this process.
基金
supported by grants from the National Key R&D Program of China(No.2017YFC1309603)
National Key Research and Development Program of China(Nos.2016YFA0101002,2018YFC2001100)
National Natural Science Foundation of China(Nos.81170736,81570715,81870579,81800703)
Beijing Natural Science Foundation(Nos.7202163,7184252)
Medical Epigenetics Research Center,Chinese Academy of Medical Sciences(Nos.2017PT31036,2018PT31021)
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.CIFMS2017-I2M-1-008)
the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Nos.2017PT32020,2018PT32001),China Diabetes Young Scientific Talent Research Project and Bethune-Merck Diabetes Research Fund of Bethune Charitable Foundation.
