糖尿病肾病及其氧化应激相关物质研究进展

Research progress in diabetic nephropathy and related substances affecting oxidative stress

糖尿病肾病(DN)是糖尿病最常见的微血管病变之一,其作为终末期肾病的主要病因,已成为世界范围内严重的公共卫生问题,但仍缺乏有效的治疗手段。既往研究证实DN的发病机制与氧化应激密切相关,氧化应激由高血糖的炎症反应引起。氧化应激的靶点包括蛋白质、脂质和核酸,它们改变了这些大分子的结构和功能。近年来研究发现,在DN的发生发展过程中,许多物质可以通过影响氧化应激的各个环节来发挥抗氧化作用,最终为预防和减轻肾脏损害提供新的思路。本文就DN的发病机制,氧化应激在DN中的作用以及影响氧化应激的相关物质等进行综述。

Diabetic nephropathy is the most common microvascular disease of diabetes. As the main cause of end-stage nephropathy, diabetic nephropathy has become a serious public health problem in the world, and there is no effective treatment.Previous studies have confirmed that the pathogenesis of diabetic nephropathy is closely related to oxidative stress, which is caused by the inflammatory response due to high blood sugar. Targets of oxidative stress include proteins, lipids, and nucleic acids, which alter the structure and function of these macromolecules. In recent years, it has been found that many substances can play an antioxidant role in the development of diabetic nephropathy by affecting various aspects of oxidative stress. Finally, it provides a new way to prevent and mitigate kidney damage. This article reviews the pathogenesis of diabetic nephropathy, the role of oxidative stress in diabetic nephropathy and the related substances affecting oxidative stress.