索拉菲尼联合射频消融术治疗对原发性肝癌患者的影响

Effect of sorafenib combined with RFA on patients with primary hepatocellular carcinoma

目的探讨索拉菲尼联合射频消融术治疗对原发性肝癌患者的影响。方法选择2017年4月至2018年9月于该院就诊的原发性肝癌患者76例,采用随机数字表法将患者分为研究组(n=38)与对照组(n=38),对照组患者行射频消融术(RFA)治疗,研究组予以索拉菲尼联合RFA治疗,比较两组血清内脂素(visfatin)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平。结果研究组患者治疗后的血清NGAL(19.27±4.31)ng/mL、visfatin(32.44±7.06)ng/mL,显著低于对照组(P<0.05)。研究组患者治疗后的血清甲胎蛋白(AFP)(73.09±20.14)ng/mL、糖链抗原-199(CA-199)(34.75±5.25)u/mL、谷氨酰转肽酶(GGT)(88.35±12.54)u/L、血管内皮细胞生长因子(VEGF)(206.50±24.65)pg/mL,显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后研究组ALT(32.6±9.6)u/L、AST(31.8±12.4)u/L、TBIL(23.4±8.5)μmol/L,均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论索拉菲尼联合RFA术治疗可抑制原发性肝癌患者血清visfatin、NGAL表达,降低血清肿瘤标志物水平,疗效良好,值得推荐。

【Objective】To investigate the effect of sorafenib combined with RFA on the expression of serum visfatin and NGAL in patients with primary liver cancer.【Methods】Seventy-six patients with primary hepatocellular carcinoma who were treated in our hospital from April 2017 to September 2018 were divided into study group(n=38)and control group(n=38)by random number table.The control group was treated by RFA.The study group was treated by sorafenib combined with RFA.The levels of serum visfatin and NGAL were compared between the two groups.【Results】The serum NGAL(19.27±4.31 ng/mL)and visfatin(32.44±7.06 ng/mL)in the study group were significantly higher than those in the control group(P<0.05).The serum AFP(73.09±20.14 ng/mL),CA-199(34.75±5.25 u/mL),GGT(88.35±12.54 u/L)and VEGF(206.50±24.65 pg/mL)in the study group were significantly lower than those in the control group after treatment,and the difference between the two groups was statistically significant(P<0.05).After treatment,ALT(32.6±9.6 u/L),AST(31.8±12.4 u/L)and TBIL(23.4±8.5μmol/L)in the study group were significantly lower than those in the control group,with a significant difference between the two groups(P<0.05).【Conclusion】Sorafenib combined with RFA can inhibit the expression of serum visfatin and NGAL in patients with primary hepatocellular carcinoma and reduce the level of serum tumor markers.It has a good therapeutic effect and is worth recommending.