碘-125放射性粒子植入治疗对肺癌化疗患者生活质量的影响

Effect of iodine-125 radioparticle implantation therapy on quality of life in lung cancer patients with chemotherapy

目的探讨碘-125(^(125)Ⅰ)放射性粒子植入治疗对肺癌患者生活质量的影响。方法选取92例中晚期肺癌患者,随机分为观察组与对照组各46例。对照组采用长春瑞滨联合顺铂方案(NP方案)进行常规化疗,观察组在常规治疗的基础上进行^(125)Ⅰ放射性粒子植入治疗。治疗12周后,比较2组临床疗效、不良反应发生情况、生活质量水平以及预后。结果观察组总有效率显著高于对照组(P<0.05)。治疗后,观察组患者的认知功能、社会功能、躯体功能、情绪功能、角色功能等各项生活质量评分均显著高于对照组(P<0.05)。观察组患者不良反应总发生率显著低于对照组(P<0.05)。2组患者1年肿瘤局部控制率和1年生存率比较,差异均无统计学意义(P>0.05);观察组患者的2年肿瘤局部控制率和2年生存率均显著高于对照组(P<0.05)。结论采用^(125)Ⅰ放射性粒子植入手段治疗中晚期肺癌患者,不仅可以有效控制局部肿瘤发展,还能够降低不良反应的发生风险,改善患者的生活质量和预后。

Objective To explore the effect of iodine-125(125Ⅰ)radioparticle implantation therapy on quality of life in patients with lung cancer.Methods A total of 92 patients with middle and advanced lung cancer were selected and randomly divided into observation group(n=46)and control group(n=46).The control group received chemotherapy of vinorelbine combined with cisplatin(NP plan),while the observation group received125Ⅰradioparticle implantation on the basis of conventional treatment.After 12 weeks of treatment,the clinical efficacy,adverse reactions,quality of life and prognosis were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the scores of cognitive function,social function,physical function,emotional function and role function in the observation group were significantly higher than those in the control group(P<0.05).The total incidence rate of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).There were no significant differences in 1-year local control rate and 1-year survival rate between the two groups(P>0.05).The 2-year local control rate and 2-year survival rate in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The125Ⅰradioparticle implantation therapy for patients with middle and advanced lung cancer can not only effectively control the development of local tumors,but also reduce the risk of adverse reactions and improve the quality of life and prognosis of patients.