聚乙二醇“1+2”口服法对慢性便秘患者肠道准备效果的影响

Effect of"1 plus 2"oral administration with polyethylene glycol on intestinal preparation in patients with chronic constipation

目的探讨聚乙二醇"1+2"口服法对慢性便秘患者拟行结肠镜前肠道准备效果的影响。方法选择行结肠镜检查的慢性便秘患者120例,随机分为对照组与观察组各60例。对照组采用聚乙二醇传统口服法进行肠道准备,观察组采用聚乙二醇"1+2"口服法进行肠道准备。采用Boston肠道准备评估量表(BBPS)评价肠道清洁效果及肠腔内气泡情况,比较2组不良反应发生情况以及肠道准备接受率。结果观察组患者BBPS评分为(8.30±0.81)分,显著高于对照组(7.60±0.89)分(P<0.01);观察组患者肠腔内气泡评分为(0.32±0.54)分,显著低于对照组(0.57±0.62)分(P<0.01)。观察组患者恶心、呕吐、腹痛、腹胀、头晕及低血糖发生率显著低于对照组(P<0.05或P<0.01)。观察组患者肠道准备接受率为66.67%,显著高于对照组41.67%(P<0.01)。结论对于慢性便秘患者的结肠镜肠道准备,聚乙二醇"1+2"口服法效果优于传统口服法,可有效提高患者肠道清洁有效率,减轻患者不适感,降低不良反应发生率,增强患者依从性及耐受性。

Objective To investigate the effect of"1 plus 2"oral administration with polyethylene glycol on intestinal preparation of colonoscopy in patients with chronic constipation.Methods Totally 120 chronic constipation patients with colonoscopy were selected and randomly divided into control group and observation group,with 60 cases in each group.The control group was prepared by traditional oral administration of polyethylene glycol,while the observation group was prepared by"1 plus 2"oral administration with polyethylene glycol.Boston Bowel Preparation Scale(BBPS)was used to evaluate the effect of intestinal cleaning and the condition of intestinal air bubbles,and the incidence of adverse reactions and acceptance rate of intestinal preparation were compared between the two groups.Results The BBPS score of the observation group was(8.30±0.81)points,which was significantly higher than(7.60±0.89)points of the control group(P<0.01).The intestinal air bubble score of the observation group was(0.32±0.54)points,which was significantly lower than(0.57±0.62)points of the control group(P<0.01).The incidence rate of nausea,vomiting,abdominal pain,abdominal distention,dizziness and hypoglycemia in the observation group was significantly lower than that in the control group(P<0.05 or P<0.01).The acceptance rate of intestinal preparation in the observation group was 66.67%,which was significantly higher than 41.67%in the control group(P<0.01).Conclusion For chronic constipation patients with intestinal preparation by colonoscopy,polyethylene glycol"1 plus 2"administration is better than the traditional oral administration,which can effectively improve the efficiency of intestinal cleaning,relieve the discomfort degree,reduce the incidence of adverse reactions,and enhance the compliance and tolerance of patients.