盐酸度洛西汀与顺风匀气汤合越鞠丸联用对脑梗死后抑郁患者的治疗效果

Effect of duloxetine hydrochloride as well as Shunfeng Yunqi Decoction combined with Yueju Pill in patients with post cerebral infarction depression

目的探讨盐酸度洛西汀与顺风匀气汤合越鞠丸联用对脑梗死后抑郁患者汉密尔顿抑郁量表(HAMD)评分与美国国立卫生院神经功能缺损量表(NIHSS)评分的影响。方法纳入80例脑梗死后抑郁患者作为研究对象,将单纯采取盐酸度洛西汀治疗的40例患者设为对照组,将加用顺风匀气汤合越鞠丸治疗的40例患者设为研究组,对2组患者治疗前后的抑郁症状、神经功能缺损程度、神经递质变化进行统计学分析。结果治疗6周后,2组HAMD评分、NIHSS评分低于治疗前,且研究组HAMD评分、NIHSS评分低于对照组,差异均有统计学意义(P <0. 05);治疗后,2组5-羟色胺(5-HT)、内皮素(ET)水平高于治疗前,且研究组5-HT、ET水平高于对照组,差异均有统计学意义(P <0. 05)。结论盐酸度洛西汀与顺风匀气汤合越鞠丸联用治疗脑梗死后抑郁的临床效果更佳,可有效减轻患者抑郁症状,改善患者神经递质相关指标水平,减轻神经功能缺损表现。

Objective To explore the effect of duloxetine hydrochloride as well as Shunfeng Yunqi Decoction combined with Yueju Pill on Hamilton Depression Scale(HAMD)and National Institutes of Health Stroke Scale(NIHSS)in patients with post cerebral infarction depression.Methods A total of 80 patients with post cerebral infarction depression diagnosed and treated in the hospital were selected as research subjects,and were divided into two groups according to different treatment plans.The patients treated with duloxetine hydrochloride alone were selected as control group(n=40),those additionally treated with Shunfeng Yunqi Decoction and Yueju Pill were selected as study group(n=40).The depression symptoms,degree of functional defect and the change of neurotransmitter of the two groups before and after treatment were analyzed.Results After 6 weeks of treatment,the HAMD scores,and NIHSS scores of the two groups were lower than before treatment(P<0.05),and the study group was lower than the control group(P<0.05);after treatment,the levels of 5-hydroxytryptamine(5-HT)and endothelin(ET)in the study group and the control group were higher than those before treatment(P<0.05),and the levels of above indicators in the study group were higher than those in the control group(P<0.05).Conclusion Duloxetine hydrochloride and Shunfeng Yunqi Decoction combined with Yueju Pill has better clinical effect in the treatment of post cerebral infarction depression,which can effectively relieve the depressive symptoms,improve the related indicators of neurotransmitters,and reduce neurological deficit.