孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的疗效评价

Efficacy evaluation of montelukast sodium combined with budesonide in the treatment of cough variant asthma in children

目的评价分析小儿咳嗽变异性哮喘治疗中孟鲁司特钠联合布地奈德的应用效果及影响。方法选取本院2016年1月至2018年12月接诊的小儿咳嗽变异性哮喘患儿90例作为研究对象,根据用药方案的不同分为对照组与观察组,各45例。两组均接受基础治疗,对照组配合布地奈德单药治疗,观察组配合孟鲁司特钠+布地奈德联合治疗。对比两组治疗效果,治疗前后炎症因子指标变化及肺功能指标变化。结果治疗前,两组炎症因子指标、肺功能指标比较差异无统计学意义;治疗后,观察组炎症因子指标、肺功能指标均较对照组明显改善,且观察组治疗效果明显优于对照组(P<0.05)。结论布地奈德与孟鲁司特钠应用于小儿咳嗽变异性哮喘治疗中,可在有效缓解炎症反应,改善患儿呼吸症状,提升治疗效果,值得临床推广。

Objective To analyze the effect and influence of montelukast sodium combined with budesonide in the treatment of children with cough variant asthma. Methods A total of 90 children with cough variant asthma admitted to our hospital from January 2016 to December 2018 were randomly selected as study subjects. According to the different medication regimens, they were divided into control group and observation group, with 45 cases in each group. The two groups received basic treatment, the control group was treated with budesonide monotherapy, and the observation group was treated with montelukast sodium+budesonide. The effects, the changes of inflammatory factors and the changes of lung function indexes before and after treatment of the two groups were compared. Results Before treatment, there was no significant difference between the two groups in inflammatory factor index and lung function index. After treatment, the inflammatory factor index and lung function index of the observation group were significantly improved compared with the control group, and the effect was significantly better than the control group(P<0.05).Conclusion The application of budesonide and montelukast sodium in the treatment of pediatric cough variant asthma can improve the respiratory restriction symptoms and improve the therapeutic effect on the basis of effective inflammatory response.