维生素D3对小儿佝偻病预防效果分析

Analysis of the preventive effect of vitamin D3 on rickets in children

目的分析维生素D3对小儿佝偻病的预防效果。方法筛选本院于2015年1月至2016年5月收治的110例高危佝偻病患儿,按照数字随机分组法分为研究组和对照组,每组55例。对照组予以常规的预防性指导,但不应用药物进行干预;研究组在对照组基础上予以维生素D3治疗,对比两组佝偻病发生情况,各项身体指标。结果研究组碱性磷酸酶水平<200 U/L患儿数明显高于对照组;研究组佝偻病发生率低于对照组;随访结束时,研究组25-(OH)D3、骨密度水平均优于对照组,两组比较差异有统计学意义(P<0.05)。结论应用维生素D3可减少高风险患儿佝偻病发生率,提高患儿发育和成长效率。

Objective To analyze the preventive effect of vitamin D3 on children with rickets. Methods 110 high-risk children admitted to our hospital from January 2015 to May 2016 were randomly divided into study group and control group by numerical randomization method, with 55 cases in each group. The control group received routine preventive guidance, but no drugs were applied. The study group increased the use of vitamin D3 on the base of control group. Compared the occurrence of rickets and various physical indicators in the two groups. Results The number of <200 U/L alkaline phosphatase levels in the study groups was significantly higher than that of the control group. The incidence of rickets in the study groups was lower than that in the control group. At the end of follow-up 25-(OH)D3 level and bone density level in the study group was superior to the control group, and the difference between the two groups was statistically significant(P<0.05). Conclusion Vitamin D3 prevention in children with rickets can reduce the probability of rickets in high-risk children, and improve the development and growth efficiency.