421人次HPV检测性别间基因型分布比较分析

Comparative analysis of genotype distribution between genders in 421 HPV tests

目的分析性别间人乳头瘤病毒(human papillomavirus,HPV)感染基因型别差异,了解某地区感染状况,为临床防治相关疾病提供诊疗依据。方法采用PCR体外扩增-DNA反向点杂交的芯片技术检测HPV感染的基因型。结果共检测421人次,其中男155人次,女266人次,总阳性检出率为58.91%。23个亚型均有检出,低危型6型和高危型16型阳性检出率最高。检测年龄范围:男18~68岁;女15~67岁,阳性者以21~30岁年龄组居多。共确认重复检测47人次,占全部检测人次数的11.16%。结论女性就诊者阳性检出率高于男性,全部就诊者阳性检出率年龄组别间和高危型感染率性别间差异无统计学意义。

Objective To analyze the genotypic differences of human papilloma virus(HPV)infection between genders and understand the status of infection in a certain region,so as to provide basis for clinical prevention and treatment of related diseases.Me thods Genotypes of HPV infection were detected by PCR in vitro amplification-DNA reverse dot hybridization microarray.Re s ults A total of 421 tests were conducted,including 155 male tests and 266 female tests.The total positive detection rate was 58.91%.All the 23 subtypes were detected,and the low risk type 6 and high risk type 16 had the highest positive detection rates.The age range of detection was 18 to 68 years for males and 15 to 67 years for females,and most of the positive patients were 21 to 30 years old.A total of 47 repeated tests were confirmed,accounting for 11.16%of the total number of tests.Conclus ion The positive detection rate of female patients was higher than that of male patients,and there was no statistically significant difference in the positive detection rate of all patients between age groups and between the genders of high-risk infection rates.