药物微生物组学:肠道微生物与个体化用药

Pharmacomicrobiomics: Gut Microbiota in Personalized Medicine

药物的安全性与有效性是临床治疗中的关键问题,大量研究表明,人体微生物与药物的疗效、不良反应等显著相关。随着人类微生物组计划的实施,药物微生物组学成为当前生命科学和医学的研究热点。药物微生物组学是药物基因组学的重要扩展和补充,致力于研究药物与微生物之间的相互作用及其与药物效应之间的关系。药物微生物组学研究尚处于起步阶段,其发展将为个体化医学和精准医疗提供必要参考。简介药物微生物组学的发展,并对肠道菌群与个体化用药的国内外研究现状进行综述。

Safety and efficacy of drugs are the key issues in clinical medication. Many studies have indicated that human microbiota are closely related with the efficacy and adverse responses of drugs. With the implementation of the human microbiome project, pharmacomicrobiomics has become a hot research area in life sciences and medicine. As an important extension and supplement of pharmacogenomics, pharmacomicrobiomics aims at investigating the interplay between drugs and microorganisms and their relationship with the efficacy of drugs. Although pharmacomicrobiomics is still in its infancy, it will provide important reference for personalized medicine and precision medicine. This article briefly reviews the development of pharmacomicrobiomics, with much focus on the current domestic and global research on the relationship between gut microbiota and personalized medicine.