纳米技术应用于帕金森病治疗的研究进展

Research Progress in the Application of Nanotechnology for the Treatment of Parkinson’s Disease

帕金森病(PD)的治疗策略主要有药物治疗、基因治疗、干细胞治疗和物理刺激疗法,这些治疗方法均存在一定的缺陷,纳米技术在解决这些问题中展现了独特的优势。纳米材料不仅是递送药物和基因的良好载体,而且一些纳米材料还表现出神经保护作用;利用纳米技术可以辅助PD的干细胞治疗,并有望刺激和调控神经活性。为了更好地认识纳米技术治疗PD的研究现状,应用该技术解决PD治疗中所面临的挑战,对纳米技术在治疗PD中的应用进展作一综述。

The treatment strategies for Parkinson’s disease(PD) principally include drug therapy, gene therapy, stem cell therapy and physical neurostimulation, yet all these therapies have certain defects. Nanotechnology, however, stands out with its unique advantages. Nanomaterials function as excellent carriers to deliver drugs and genes, some of which also have neuroprotective effects. Besides, it is promising to utilize nanotechnology in stem cell therapy or neurostimulation. This paper reviews the research and trend of nanotechnology in PD therapy, aiming at a better comprehension of its application so as to deal with the challenges for the treatment of PD.