舒巴坦联合胰岛素泵治疗糖尿病并发呼吸道感染的有效性及对患者血糖、TNF-α、IL-6水平的影响

Efficacy of sulbactam combined with insulin pump in the treatment of diabetes mellitus complicated with respiratory tract infection and its influence on the levels of blood glucose,TNF-αand IL-6 in patients

目的分析舒巴坦联合胰岛素泵治疗糖尿病并发呼吸道感染的有效性及对患者血糖、TNF-α、IL-6水平的影响。方法以2016年9月至2017年9月我院接收并诊治的74例糖尿病并发呼吸道感染患者为研究对象,采用随机数字法将其分为参照组和试验组,各37例。参照组在常规治疗的基础上采用舒巴坦联合胰岛素皮下注射进行治疗,试验组在常规治疗的基础上采用舒巴坦联合胰岛素泵进行治疗。比较两组治疗前及治疗3个月后的空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、肿瘤坏死因子-α(TNF-α)、白介素(IL-6)水平及治疗3个月后的临床疗效和不良反应发生情况。结果治疗3个月后,两组的FBG、2 h PBG、HbA1c、TNF-α、IL-6水平均降低,且试验组明显低于参照组(P<0.05)。治疗3个月后,试验组的临床治疗总有效率明显高于参照组,不良反应总发生率明显低于参照组(P<0.05)。结论舒巴坦联合胰岛素泵治疗糖尿病并发呼吸道感染的有效性显著,可改善患者的血糖、TNF-α、IL-6水平,降低不良反应发生率,值得临床推广应用。

Objective To analyze the efficacy of sulbactam combined with insulin pump in the treatment of diabetes mellitus complicated with respiratory tract infection and its influence on the levels of blood glucose,TNF-αand IL-6 in patients.Methods A total of 74 patients with diabetes mellitus complicated with respiratory tract infection received and treated in our hospital from September 2016 to September 2017 were selected as the study objects.The patients were divided into reference group and experimental group by random number method,with 37 cases in each group.The control group was treated with sulbactam combined with subcutaneous injection of insulin on the basis of conventional treatment,and the experimental group was treated with sulbactam combined with insulin pump on the basis of conventional treatment.The levels of fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1 c),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)before and after 3 months of treatment,clinical efficacy and adverse reactions after 3 months of treatment were compared between the two groups.Results After 3 months of treatment,the levels of FBG,2 h PBG,HbA1 c,TNF-α,and IL-6 in both groups decreased,and those in the experimental group were significantly lower than the control group(P<0.05).After 3 months of treatment,the total effective rate of clinical treatment in the experimental group was significantly higher than that in the reference group,and the total incidence of adverse reactions was significantly lower than that in the reference group(P<0.05).Conclusion Sulbactam combined with insulin pump in the treatment of diabetes mellitus complicated with respiratory tract infection has significant efficacy,improve the levels of blood glucose,TNF-α,IL-6,and decrease the incidence of adverse reactions,which is worthy of clinical popularization and application.