羟苯磺酸钙胶囊联合血管紧张素转换酶组织抑制剂对早期糖尿病肾病患者肾功能及血清结缔组织生长因子、金属蛋白酶抑制剂-1水平的影响

Effects of calcium dobesilate capsule combined with angiotensin-converting enzyme inhibitor on renal function,serum connective tissue growth factor and tissue inhibitor metalloproteinase-1 levels in patients with early diabetic nephropathy

目的探讨羟苯磺酸钙胶囊+血管紧张素转换酶抑制剂对早期糖尿病肾病患者肾功能及血清结缔组织生长因子(CTGF)、金属蛋白酶抑制剂-1(TIMP-1)水平的影响。方法将我院2015年1月至2018年1月收治的112例早期糖尿病肾病患者采用随机数字表法分为对照组(n=56)与研究组(n=56)。对照组采取血管紧张素转换酶抑制剂治疗,研究组在对照组基础上采取羟苯磺酸钙胶囊治疗。比较两组临床疗效、治疗前、后血清肌酐(Scr)、尿素氮(BUN)、尿酸(UA)、β2-微球蛋白(β2-MG)、CTGF、TIMP-1水平、24 h尿蛋白定量及不良反应发生情况。结果研究组治疗总有效率高于对照组(P<0.05)。治疗后,研究组血清Scr、BUN、UA、β2-MG、CTGF、TIMP-1水平及24 h尿蛋白定量低于对照组(P<0.05)。两组不良反应总发生率无显著差异(P>0.05)。结论早期糖尿病肾病患者采取羟苯磺酸钙胶囊+血管紧张素转换酶抑制剂治疗效果确切,能改善其肾功能,降低血清CTGF、TIMP-1水平,且安全性高。

Objective To investigate the effects of calcium dobesilate capsule combined with angiotensin-converting enzyme inhibitor on renal function,serum connective tissue growth factor(CTGF)and tissue inhibitor metalloproteinase-1(TIMP-1)levels in patients with early diabetic nephropathy.Methods A total of 112 patients with early diabetic nephropathy admitted in our hospital from January 2015 to January 2018 were divided into control group(n=56)and study group(n=56)according to the random number table method.The control group was treated with angiotensin-converting enzyme inhibitor,and the study group was treated with calcium dobesilate capsule on the basis of the control group.The clinical efficacy,the levels of serum creatinine(Scr),urea nitrogen(BUN),uric acid(UA),β2-microglobulin(β2-MG),CTGF,TIMP-1,24 h urine protein quantity before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the levels of serum Scr,BUN,UA,β2-MG,CTGF,TIMP-1 and 24 h urine protein quantity in the study group were lower than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion For patients with early diabetic nephropathy,calcium dobesilate capsule+angiotensin-converting enzyme inhibitor is effective,which can improve renal function,reduce serum CTGF and TIMP-1 levels,and has high safety.