甲硝唑预防剖宫产患者术后感染的效果

Effect of metronidazole on prevention of postoperative infection in cesarean section patients

目的探讨甲硝唑预防剖宫产患者术后感染的效果。方法选择本院2017年9月至2019年5月收诊的42例剖宫产患者,采用等距抽样法将其分为观察组(甲硝唑联合头孢类抗生素)与对照组(头孢类抗生素),各21例。比较两组用药前、后PCT、CRP、ESR、IFN-γ、TNF-α、NO水平、恢复情况及并发症发生情况。结果用药后,两组的PCT、CRP、ESR、IFN-γ、TNF-α、NO水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的住院时间、下床活动时间、抗生素使用时间均短于对照组,差异具有统计学意义(P<0.05)。观察组的高热、腹壁切口感染与粘连发生率均低于对照组,差异具有统计学意义(P<0.05)。结论甲硝唑可降低剖宫产患者的并发症发生率,缩短患者恢复时间,并可对患者的炎症反应作一定改善,值得使用推广。

Objective To investigate the effect of metronidazole on prevention of postoperative infection in cesarean section patients.Methods A total of 42 cesarean section patients who were admitted in our hospital from September2017 to May 2019 were selected and divided into observation group(metronidazole combined with cephalosporin antibiotics)and control group(cephalosporin antibiotics)by isometric sampling,with 21 cases in each group.The levels of PCT,CRP,ESR,IFN-γ,TNF-α,NO before and after medication,recovery and complications were compared between the two groups.Results After treatment,the levels of PCT,CRP,ESR,IFN-γ,TNF-α,and NO in both groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).The hospital stay,time of getting out of bed,and duration of antibiotic medication in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).The incidences of high fever,abdominal wall incision infection and adhesion in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Metronidazole can reduce the incidence of complications in patients with cesarean section,shorten the recovery time,and improve the inflammatory response to some extent,which is worthy of use and promotion.