加味星蒌承气汤对痰热腑实证急性脑梗死静脉溶栓后氧化应激反应的影响

Effect of modified Xinglou Chengqi Decoction on oxidative stress reactions in patients with acute cerebral infarction differentiated as phlegm-heat and sthenic-fu syndrome after intravenous thrombolysis

目的探讨加味星蒌承气汤对痰热腑实证急性脑梗死静脉溶栓后氧化应激的影响。方法选取80例痰热腑实证急性脑梗死患者,按照随机数字表表法将其分为对照组(n=40)与研究组(n=40)。对照组患者静脉溶栓后给予常规西医治疗,研究组在此基础上于溶栓当日加用加味星蒌承气汤治疗。分析2组临床疗效,并观察治疗前后氧化应激、炎性因子水平变化情况。结果与对照组比较,研究组总有效率显著较高(P<0.05);治疗后,研究组丙二醛(MDA)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平均低于对照组,超氧化物歧化酶(SOD)水平高于对照组,差异有统计学意义(P<0.05)。结论加味星蒌承气汤对痰热腑实证急性脑梗死静脉溶栓后的疗效确切,可有效改善氧化应激指标及炎症因子水平,促进神经修复。

Objective To investigate the effect of modified Xinglou Chengqi Decoction on oxidative stress reactions in patients with acute cerebral infarction differentiated as phlegm-heat and sthenic-fu syndrome after intravenous thrombolysis.Methods A total of 80 patients with acute cerebral infarction differentiated as phlegm-heat and sthenic-fu syndrome who admitted in our hospital were selected,and were divided into control group(n=40)and research group(n=40)according to random number table method.Control group was given routine western medicine after intravenous thrombolysis,and research group was treated with modified Xinglou Chengqi Decoction on thrombolysis day based on the control group.The clinical efficacy of two groups was analyzed.The oxidative stress reactions and inflammatory factors before and after treatment were observed.Results The total effective rate of research group was significantly higher than that of control group(P<0.05).After treatment,the levels of malondialdehyde(MDA),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)in research group were lower,and the superoxide dismutase(SOD)was higher than that of control group(P<0.05).Conclusion Modified Xinglou Chengqi Decoction in treatment of phlegm-heat and sthenia-fu syndrome of acute cerebral infarction after intravenous thrombolysis is effective,it can improve oxidative stress indexes and levels of inflammatory factors,and promote nerve restoration.