长春西汀联合氯化钠注射液治疗脑梗死伴重度高血压患者的疗效观察

Effect of vinpocetine combined with sodium chloride injection in the treatment of cerebral infarction patients with severe hypertension

目的探讨长春西汀联合氯化钠注射液对脑梗死伴重度高血压患者的疗效。方法选取脑梗死伴重度高血压患者86例,采用随机双盲法分为对照组(氯化钠注射液治疗)与观察组(氯化钠注射液联合长春西汀治疗)。比较2组患者治疗前后神经功能指标、血液流变学指标、白细胞介素水平。结果观察组临床总有效率95.35%,显著高于对照组74.42%(P<0.05)。2组治疗后美国国立卫生研究院卒中量表(NIHSS)评分较治疗前显著降低,且观察组显著低于对照组(P<0.05)。2组治疗后全血高切黏度、红细胞聚集指数及红细胞比容较治疗前显著降低,且观察组显著低于对照组(P<0.05)。2组治疗后白介素-12(IL-12)、白介素-23(IL-23)水平显著低于治疗前,且观察组显著低于对照组(P<0.05)。结论长春西汀联合氯化钠注射液治疗脑梗死伴重度高血压患者安全、有效,可显著改善患者神经功能及血液流变学指标。

Objective To investigate the clinical effect of vinpocetine combined with sodium chloride injection in treatment of cerebral infarction patients with severe hypertension.Methods Eighty-six cerebral infarction patients with severe hypertension were divided into two groups by random double-blind method,named as control group(n=43,treated with sodium chloride injection)and observation group(n=43,treated with vinpocetine and sodium chloride injection).Neurological function indexes,hemorheology indexes and interleukin level were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 95.35%,which was significantly higher than 74.42%of the control group(P<0.05).The score of National Institutes of Health Stroke Scale(NIHSS)in both groups was significantly lower than that before treatment,and the score of NIHSS in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the whole blood high-sheared viscosity,erythrocyte aggregation index and hematocrit of the two groups were significantly lower than those before treatment,and these indexes in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of interleukin-12(IL-12)and interleukin-23(IL-23)in both groups were significantly lower than those before treatment,and the levels of these indexes in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Vinpocetine combined with sodium chloride injection is safe and effective in the treatment of cerebral infarction patients with severe hypertension,which can significantly improve the neurological function and hemorheological indexes.