布地奈德联合盐酸氨溴索雾化吸入对150例支气管肺炎患儿血清IL-8、SOD、IGF-Ⅱ水平的影响

Effects of Aerosol Inhalation of Budesonide Combined with Ambroxol Hydrochloride on Levels of Serum IL-8,SOD and IGF-Ⅱ in 150 Children Patients with Bronchial Pneumonia

目的探究布地奈德与盐酸氨溴索混悬液雾化吸入对小儿支气管肺炎中血清白细胞介素-8(IL-8)、超氧化物歧化酶(SOD)、胰岛素样生长因子Ⅱ(IGF-Ⅱ)水平的影响。方法将2017年2月至2018年2月在我院进行治疗的150例小儿支气管肺炎的患儿作为研究对象。按照随机数表法分配为实验组和对照组,各75例。两组均进行抗炎、祛痰等基础治疗,对照组给予盐酸氨溴索雾化吸入,实验组在对照组疗法之上,联用布地奈德吸入。在1疗程后比较两组的临床疗效,临床症状好转所需时间,检测治疗前后患儿血清IL-8、SOD、IGF-Ⅱ水平变化。结果与对照组相比较,实验组在治疗后咳嗽、咳痰、肺部湿啰音等症状好转所需时间明显更短,具有统计学意义(P<0.05)。实验组的临床疗效有效率(89.33%),高于对照组的临床有效率(73.33%),具有统计学意义(P<0.05)。与对照组相比,实验组在治疗后的患儿血清IL-8和IGF-Ⅱ降低幅度,SOD升高幅度明显更高,具有统计学意义(P<0.05)。两组均无不良反应。结论布地奈德与盐酸氨溴索悬液联合吸入,在小儿支气管肺炎治疗中疗效显著,可降低体内炎症因子,增强抗氧化能力,纠正IGF-Ⅱ。

Objective To explore the effects of aerosol inhalation of budesonide and ambroxol hydrochloride suspension on levels of serum interleukin-8(IL-8),superoxide dismutase(SOD)and insulin-like growth factor Ⅱ(IGF-Ⅱ)in children with bronchial pneumonia.Methods A total of 150 children patients with bronchial pneumonia who were treated in our hospital from February 2017 to February 2018 were selected for the study.According to the random number table method,the patients were divided into experimental group and control group,with 75 cases in each group.The two groups were given basic treatments of anti-inflammation and eliminating phlegm,and control group was given aerosol inhalation of ambroxol hydrochloride,and experimental group was combined with budesonideinhalation on the basis of control group.After 1 course of treatment,the clinical efficacy and required times for improvement of clinical symptoms were compared between the two groups,and the changes of levels of serum IL-8,SOD and IGF-Ⅱ were detected before and after treatment.Results Compared with control group,therequired times for improvement of clinical symptoms of cough,expectoration,and lung wet rales in experimental group were significantly shorter(P<0.05).Theeffective rate of clinical efficacy in experimental group was higher than that in control group(89.33%vs 73.33%)(P<0.05).Compared with control group,the decreases of serum IL-8 and IGF-Ⅱ and the increase of SOD were significantly higher in experimental group after treatment(P<0.05).There were no adverse reactions in the two groups.Conclusion Budesonide combined with ambroxol hydrochloride suspension has significant efficacy in the treatment of children with bronchial pneumonia,and it can reduce inflammatory factors in the body,enhance antioxidant capacity,and correct IGF-Ⅱ.