稳心颗粒联合阿托伐他汀治疗阵发性房颤的效果及对心功能、血清NT-proBNP水平的影响

Effects of Wenxin Granule Combined with Atorvastatin on Paroxysmal Atrial Fibrillation and its Influence on Cardiac Function and Serum NT-proBNP Level

目的探讨稳心颗粒联合阿托伐他汀治疗阵发性房颤(PAF)的效果及对心功能、血清N末端B型脑钠肽(NT-proBNP)水平的影响。方法将我院2016年1月至2018年1月收治的52例PAF患者随机分为观察组和对照组,各26例,对照组采用阿托伐他汀治疗,观察组在对照组基础上加用稳心颗粒联合治疗,两组均治疗6个月后评定疗效,并测定患者治疗前后左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)、心脏指数(CI)、心搏量(SV)等心功能指标变化,分别于治疗前、治疗后1、3、6个月测定患者血清中NT-proBNP水平。结果观察组患者临床有效率为92.31%,明显高于对照组的69.23%(P<0.05);治疗后观察组LVESD、LVEDD等心功能指标明显低于对照组,LVEF、CI、SV等指标明显高于对照组(P<0.05);治疗后两组NT-proBNP水平均明显降低,观察组降低幅度高于对照组(P<0.05)。结论稳心颗粒联合阿托伐他汀治疗PAF效果显著,可明显改善心功能,降低NT-proBNP水平。

Objective To explore the effects of Wenxin granule combined with atorvastatin on paroxysmal atrial fibrillation(PAF)and its influence on cardiac function and serum N-terminal B-type brain natriuretic peptide(NT-proBNP).Methods 52 cases of patients with PAF admitted to our hospital from January 2016 to February 2018 were randomly divided into observation group and control group,with 26 cases in each group.Control group was given atorvastatin,and observation group was added with Wenxin granule on the basis of control group.The efficacy was evaluated after 6 months of treatment.The cardiac function indicators of left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),cardiac index(CI)and stroke volume(SV)were measured before and after treatment,and the serum level of NT-proBNP was measured before treatment and at 1,3,and 6 months after treatment.Results The clinical effective rate in observation group was significantly higher than that in control group(92.31%vs 69.23%)(P<0.05).After treatment,the cardiac function indexes of LVESD and LVEDD in observation group were significantly lower than those in control group while the levels of LVEF,CI and SV were significantly higher than those in control group(P<0.05).The level of NT-proBNP was significantly decreased in the two groups after treatment,and the decrease in observation group was greater than that in control group(P<0.05).Conclusion Wenxin granule combined with atorvastatin has significant effectson PAF,and it can significantly improve cardiac function and reduce NT-proBNP level.