螺内酯辅助治疗难治性高血压的效果及对24h血压变异性的影响

Effect of Spironolactone in the Treatment of Refractory Hypertension and the Influence on 24h Blood Pressure Variability

目的研究螺内酯辅助治疗难治性高血压的效果及对24h血压变异性的影响。方法随机数表法将本院2017年1月-2018年9月诊治的202例难治性高血压患者分为研究组与对照组,各101例,对照组给予常规降压治疗,研究组给予螺内酯联合常规降压治疗。连续治疗2个月后评价两组患者的疗效、24h血压变异性指标变化情况。结果研究组治疗有效率为91.09%,明显高于对照组的71.29%(P<0.05);与治疗前相比,两组患者治疗后血压指标水平以及血压变异性程度均有所下降,但研究组dSBP(白天收缩压)、dDBP(白天舒张压)等血压水平以及血压变异性程度下降较对照组更为明显(P<0.05)。结论螺内酯辅助治疗RH可有效提高疗效,降低患者血压变异性程度,改善血压水平。

Objective To study the effect of spironolactone in the treatment of refractory hypertension(RH)and the influence on 24h blood pressure variability.Methods 202 patients with RH diagnosed and treated in the hospital between January 2017 and September 2018 were divided into the study group and the control group by the random number table method,with 101 patients in each group.The control group were given routine antihypertensive therapy,and the study group were treated with spironolactone combined with conventional antihypertensive therapy.After 2 months of continuous treatment,the curative effect and changes in 24hblood pressure variability indexeswere evaluated.Results The effective rate of treatment in the study group(91.09%)was significantly higher than that in the control group(71.29%)(P<0.05).Levels of blood pressure indexes and blood pressure variability in both groupsdecreased after treatment,but thedecrease indSBP(daytime systolic blood pressure),dDBP(daytime diastolic blood pressure)and blood pressure variability was more obvious in the study groupthan in the control group(P<0.05).Conclusion Spironolactone-assisted treatment for RH can effectively improve the curative effect,reduce the degree of blood pressure variability and improve blood pressure.