GBS感染胎膜早破孕妇抗感染治疗对妊娠结局、新生儿情况的干预分析

Intervention Effect of Anti-infection Treatment on Pregnancy Outcomes and Neonatal Status in GBS Infected Pregnant Women with Premature Rupture of Membranes

目的探讨抗感染治疗对B族链球菌(GBS)感染胎膜早破孕妇妊娠结局及新生儿情况的干预作用。方法收集2013年2月~2017年1月在我院住院分娩的70例GBS感染胎膜早破孕妇的临床资料,其中接受抗感染治疗38例(观察组),未接受抗感染治疗32例(对照组),比较两组妊娠结局、新生儿出生体重及出生1min、5minApgar评分,统计新生儿不良事件发生率。结果①GBS感染胎膜早破孕妇其GBS菌株对青霉素敏感率为95.71%,对克林霉素敏感率为88.57%、利福平为84.29%;②观察组剖宫产率、宫内感染、产褥期感染发生率低于对照组(P<0.05);③观察组新生儿感染发生率低于对照组,对比差异有统计学意义(P<0.05);④观察组出生1min、出生5minApgar评分均高于对照组(P<0.05)。结论 GBS感染胎膜早破孕妇采用抗感染治疗可改善其母婴结局,减少剖宫产率,降低新生儿不良事件发生风险。

Objective To investigate the intervention effect of anti-infection treatment on pregnancy outcomes and neonatal status in Group B Streptococcus(GBS) infected pregnant women with premature rupture of membranes. Methods The clinical data of 70 GBS infected pregnant women with premature rupture of membranes who were hospitalized in our hospital and delivered during February 2013 to January 2017 were collected. Among them, 38 cases were given anti-infection treatment(observation group) and 32 cases were not given anti-infection treatment(control group). Pregnancy outcomes, newborn birth weight and Apgar scores at 1 min and 5 min after delivery were compared between the two groups. The incidence of neonatal adverse events was statistically analyzed. Results ①The susceptibility rate of GBS strain to penicillin was 95.71%, to clindamycin was 88.57%, and to rifampin was 84.29% in GBS infected pregnant women with premature rupture of membranes. ②The incidence rates of cesarean section, intrauterine infection and puerperal infection were lower in the observation group than in the control group(P<0.05). ③The incidence of neonatal infection in the observation group was lower than that in the control group(P<0.05). ④Apgar scores of the observation group at 1 min and 5 min after delivery were higher than those of the control group(P<0.05). Conclusion Anti-infection treatment can improve the maternal and neonatal outcomes, reduce the cesarean section rate and reduce the risk of neonatal adverse events in GBS infected women with premature rupture of membranes.