康复消炎栓联合左氧氟沙星治疗慢性盆腔炎的疗效及炎症因子变化观察

Effect of Rehabilitation and Anti-inflammatory Suppository Combined with Levofloxacin on Chronic Pelvic Inflammatory Disease and Observation of Inflammatory Factors

目的观察康复消炎栓联合左氧氟沙星对慢性盆腔炎患者的疗效及对炎症因子变化的影响。方法将本院2018年2月至2019年2月收治的240例慢性盆腔炎患者作为研究对象,按随机数表法分为两组,各120例。对照组单独使用左氧氟沙星进行治疗,实验组在对照组的治疗方法上联合使用康复消炎栓进行治疗。2个疗程后比较2组的临床疗效,对治疗前后2组症状消失所需时间和血清中的白细胞介素(IL-1β)、血清C反应蛋白(CRP)、干扰素(IFN-γ)、白介素-8(IL-8)水平进行对比。结果实验组总有效率85.83%,高于对照组70.83%,差异有统计学意义(P<0.05)。与对照组相比,实验组2疗程后月经不调、腰骶疼痛、腹痛、白带增多或减少等症状解除更快,具有统计学意义(P<0.05)。治疗后实验组患者的血清IFN-γ、CRP、IL-1β和IL-8水平均明显低于对照组,相比较具有统计学意义(P<0.05)。结论康复消炎栓与左氧氟沙星联合治疗对慢性盆腔炎患者疗效显著,能有效减少临床症状消失时间及缓解炎症反应。

Objective To observe the effect of rehabilitation and anti-inflammatory suppository combined with levofloxacin on chronic pelvic inflammatory disease and observation of inflammatory factors. Methods 240 patients with chronic pelvic inflammatory disease admitted to our hospital from February 2018 to February 2019 were enrolled in the study. They were divided into two groups according to the random number table method, 120 cases each. The control group was treated with levofloxacin alone, and the experimental group was treated with rehabilitation and anti-inflammatory suppository on this basis. Compare the clinical efficacy of 2 groups after 2 courses of treatment. The time required for the disappearance of symptoms in the two groups before and after treatment and the levels of interleukin(IL-1β), serum C-reactive protein(CRP), interferon(IFN-γ), and interleukin-8(IL-8) in serum were compared. Results The total effective rate of the experimental group was 85.83%, which was higher than that of the control group(70.83%). The difference was statistically significant(P<0.05). Compared with the control group, the irregular menstruation, lumbosacral pain, abdominal pain, increased or decreased vaginal discharge, and other symptoms were relieved faster in the experimental group. The difference was statistically significant after 2 courses of treatment(P<0.05). After treatment, the serum levels of IFN-γ, CRP, IL-1β and IL-8 in the experimental group were significantly lower than those in the control group(P<0.05). Conclusion The combination of rehabilitation and antiinflammatory suppository and levofloxacin has significant curative effect on patients with chronic pelvic inflammatory disease, which can effectively reduce the disappearance of clinical symptoms and relieve inflammation.