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层状高分子刷表面及其生物医用

Surfaces functionalized with hierarchical polymer brushes and their biomedical applications
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摘要 表面改性是赋予生物医用材料表面所需功能和性能的最佳途径之一.高分子刷改性表面具有制备简单、表面化学可控、耐久性和稳定性好等优点,近年来发展迅猛.其中,层状高分子刷表面引起了人们极大的研究兴趣.层状高分子刷将不同接枝链段构建在不同空间层上,不仅接枝链段间密度和功能相互干扰小,而且通过结构和组成设计,协同利用不同高分子刷层在温度、溶剂、pH等外界环境下的响应差异,能获得单层高分子刷很难实现的生物自适应性.本文系统地概述了层状高分子刷的构建方法、表面结构与性能关系,结合本课题组的相关研究工作,综述了层状高分子刷在生物医用领域的研究进展,最后展望了层状高分子刷医用表面的发展前景和趋势. Surface modification is one of the best ways to impart the biological functions and properties to the surface of biomedical material. Surface modification with polymer brushes has been developed rapidly due to the advantages of simple preparation, controllable surface chemistry, good durability and stability. Among them, the hierarchical polymer brushes have aroused great interests due to the characteristic that the different grafted chain segments are constructed on different spatial layers, which largely reduce the mutual interferences(e.g., grafted density, biological functions)between the different grafted chain segments. More importantly, by rational structure and composition design, the different responses of the different grafted chain segments to external environments(e.g., temperature, solvent, pH) have been used to facilely obtain biological adaptability, which is difficult to be provided by the single-layer polymer brushes.In this review, we present a descriptive review of the construction method of hierarchical polymer brush and the relationship between surface structure and performances. Furthermore, based on our group’s work, the research progress of hierarchical polymer brush in the biomedical application is summarized, and the related prospect is highlighted as well.
作者 杨然 殷敬华 闫顺杰 栾世方 Ran Yang;Jinghua Yin;Shunjie Yan;Shifang Luan(State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;College of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China;National Engineering Laboratory of Medical Implantable Devices,Key Laboratory for Medical Implantable Devices of Shandong Province,WEGO Holding Company Limited,Weihai 264210,China)
出处 《中国科学:化学》 CAS CSCD 北大核心 2020年第4期447-462,共16页 SCIENTIA SINICA Chimica
基金 国家自然科学基金(编号:51873213,51973081,51473167) 国家重点研发计划(编号:2017YFC1104800) 中国博士后基金(编号:2017M621225) 中国科学院-威高研究发展计划项目资助。
关键词 层状高分子刷 活性接枝聚合 表面结构与性能 抗细菌感染 生物医用检测 hierarchical polymer brush living grafting polymerization surface structure and performances antibacterial biomedical detection
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