年轻三阴性乳腺癌患者戈舍瑞林用药依从性调查及分析

Investigation and analysis of goserelin medication compliance in triple-negative young breast cancer patients

目的了解年轻三阴性乳腺癌(triple negative breast cancer,TNBC)患者使用戈舍瑞林保护卵巢功能的现状。方法回顾性收集2015年1月至2017年12月重庆医科大学附属第一医院乳腺外科经病理确诊为TNBC且有保护卵巢功能意愿的患者共47例,计算患者的戈舍瑞林药物占有比,通过电话随访方式调查患者的用药情况。结果成功随访31例,中位年龄31岁,年龄范围为14~41岁。80.6%(25/31)的患者戈舍瑞林用药依从性好,19.4%(6/31)的患者依从性差。Fisher精确检验显示,文化程度、经济情况和医保类型对戈舍瑞林依从性有影响,差异有统计学意义(P<0.05)。结论医护人员应多关注文化程度较低、经济条件较差TNBC患者的戈舍瑞林用药情况,为患者提供科学的用药指导和个体化的健康教育,做好患者的全程管理,提高患者的用药依从性。

Objective To understand the current status of the use of goserelin for protection of ovarian function in young patients with triple-negative breast cancer.Methods Clinical data of 47 patients pathologically diagnosed as triple-negative breast cancer from Jan.2015 to Dec.2017 and with a willingness to protect ovarian function were collected and retrospectively analyzed.Patients’drug share was calculated,and drug use was investigated by telephone follow-up.Results 31 patients were successfully followed up,aged 14-40 years,with a median age of 31 years.80.6%(25/31)patients had a compliance and 19.4%(6/31)patients had poor compliance.Fisher’s exact test showed that the degree of education,economic situation and type of medical insurance had an impact on compliance,and the difference was statistically significant(P<0.05).Conclusion Medical staff should pay more attention to the use of drugs in patients with lower education level and poor economic conditions,provide them with scientific medication guidance and individualized health education,do a good job of patient management,and improve patient compliance.