具有微乳头状结构的乳腺单纯型黏液癌临床病理特征

Clinicopathological features micropapillary pattern of pure mucinous carcinoma of the breast

回顾性分析东阳市人民医院5例乳腺具有微乳头状结构的单纯型黏液癌(micropapillary pattern of pure mucinous carcinoma of the breast,MPPPMC)的临床病理特征。本组5例具有MPPPMC均为绝经前女性,年龄范围为37~48岁,5例患者中3例伴有腋窝淋巴结转移,3例患者行乳房改良根治术、1例保乳+前哨淋巴结活检、1例保乳+腋窝淋巴结清扫,术后1例口服内分泌药物+放疗、4例口服内分泌药物+化疗+放疗、2例靶向药物赫赛汀治疗。具有MPPPMC是一种界于单纯型黏液癌(pure mucinous carcinoma,PMC)与浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)之间的特殊类型,该类型发病年龄较黏液癌年轻,预后较黏液癌差,是否是乳腺IMPC或PMC的一种独立亚型目前仍未达成共识。

The clinicopathological features of 5 cases of micropapillary pattern of pure mucinous carcinoma(MPPPMC)of the breast were analyzed retrospectively.In this group,5 cases of MPPPMC were all premenopausal women,whose age ranged from 37 to 48 years old.3 cases had axillary lymph node metastasis,3 cases had modified radical mastectomy,1 case had breast conserving and sentinel lymph node biopsy,1 case had breast conserving and axillary lymph node dissection,1 case had oral endocrine drug and radiotherapy,4 cases had oral endocrine drug and chemotherapy and radiotherapy,and 2 cases had oral targeted drug herceptin treatment.MPPPMC pattern is a kind of special type of pure mucinous carcinoma and invasive micropapillary carcinoma.The age of onset of this type is younger than that of mucinous carcinoma,and the prognosis of this type is worse than mucinous carcinoma.Whether it is an independent subtype of breast invasive micropapillary carcinoma or mucinous carcinoma has not reached consensus.