儿童重症腺病毒肺炎的发病机制进展

Advances in the pathogenesis of severe adenovirus pneumonia in children

人腺病毒是引起婴幼儿急性呼吸道感染的主要病原体,且易引起重症腺病毒肺炎、呼吸窘迫综合征而导致死亡,也可遗留不同程度的后遗症。重症腺病毒肺炎的治疗仍是当今临床儿科医生面临的难题。人腺病毒致重症腺病毒肺炎的发病机制仍不清楚,目前认为,腺病毒肺炎发生、发展的主要诱发因素是免疫功能低下和病毒感染后免疫功能紊乱。本文就人腺病毒致腺病毒肺炎发病机制相关研究进展进行综述。

Human adenovirus is one of the most important pathogen causing acute respiratory infections in infants and young children,and is easy to cause severe adenovirus pneumonia and respiratory distress syndrome,which can cause death and varying degrees of sequelae.The pathogenesis of human adenovirus-induced severe adenovirus pneumonia remains unclear.It is currently believed that the main predisposing&factors for the occurrence and development of adenovirus pneumonia are immune dysfunction and immune dysfunction after viral infection.This article reviewed the research progress on the pathogenesis of adenovirus pneumonia induced by human adenovirus.