乙型肝炎患者体液免疫功能、肝纤维化指标及α1-MG、TGF-β1水平分析

Analysis of the Humoral Immune Function, Hepatic Fibrosis Index and Levels of α1-MG and TGF-β1 in Patients with Hepatitis B

目的:探讨乙型肝炎患者体液免疫功能、肝纤维化程度及血清中α1-MG、TGF-β1水平的变化。方法:选取2016年1月~2018年10月我院收治的轻度乙型肝炎患者60例为轻度组,重度乙型肝炎患者60例为重度组及同期来我院体检的健康志愿者60例为对照组。检测并比较三组患者血清中补体C3、补体C4、肝纤维化指标及α1-微球蛋白(α1-MG)、转化生长因子-β1(TGF-β1)水平。结果:乙型肝炎患者血清中补体C3及补体C4水平明显低于对照组;重度组患者血清中补体C3及补体C4水平明显低于轻度组患者(P<0.05)。乙型肝炎患者血清中各肝纤维化指标水平明显高于对照组;重度组患者血清中各肝纤维化指标水平明显高于轻度组患者(P<0.05)。乙型肝炎患者血清中α1-MG水平明显低于对照组,TGF-β1水平明显高于对照组;重度组患者血清中α1-MG水平明显低于轻度组,TGF-β1水平明显高于轻度组(P<0.05)。结论:乙型肝炎病毒感染可导致患者免疫功能水平下降,肝脏纤维化及细胞因子水平紊乱,且上述指标水平的变化与疾病进展程度密切相关,临床治疗时需加强对上述指标的监测。

Objective: To investigate the changes of humoral immune function, degree of liver fibrosis and serum levels of α1-MG and TGF-β1 in patients with hepatitis B. Methods: 60 patients with mild hepatitis B were selected as mild group and 60 patients with severe hepatitis B were selected as severe group from January 2016 to October 2018. During the same period, 60 healthy volunteers in our hospital were selected as control group. The levels of complement C3, complement C4, liver fibrosis index, α1-microglobulin(α1-MG) and transforming growth factor-β1(TGF-β1) of patients in the three groups were detected and compared. Results: The serum levels of complement C3 and complement C4 in patients with hepatitis B were significantly lower than those in the control group. The serum levels of complement C3 and complement C4 of patients in severe group were significantly lower than those in mild group(P<0.05).The serum levels of liver fibrosis indexes in patients with hepatitis B were significantly higher than those in the control group. The serum levels of liver fibrosis indexes of patients in severe group were significantly higher than those in mild group(P<0.05). The serum levels ofα1-MG in patients with hepatitis B was significantly lower than those in the control group, and the levels of TGF-β1 was significantly higher than that in the control group. The serum levels of α1-MG in severe group were significantly lower than those in mild group, and the level of TGF-β1 were significantly higher than those in mild group(P<0.05). Conclusion: Hepatitis B virus infection can lead to the decline of immune function, liver fibrosis and cytokine disorders, and the changes of these indicators are closely related to the degree of disease progression. The monitoring and intervention of the above indicators should be strengthened in clinical treatment.