艾瑞昔布联合正清风痛宁缓释片治疗类风湿关节炎的疗效分析

Efficacy analysis of imrecoxib combined with Zhengqing Fengtongning Sustained Release Tablets in the treatment of rheumatoid arthritis

目的探讨艾瑞昔布联合正清风痛宁缓释片治疗类风湿关节炎的疗效。方法将97例类风湿关节炎患者随机分为实验组(n=50)与对照组(n=47)。实验组予以艾瑞昔布及正清风痛宁缓释片治疗,对照组予以艾瑞昔布治疗。比较2组治疗前后红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子、肿胀关节数、疼痛视觉模拟评分(VAS)、总有效率及总显效率。结果治疗后,2组ESR、CRP、类风湿因水平均较治疗前降低,且实验组ESR水平低于对照组,差异有统计学意义(P<0.05)。治疗后,2组关节肿痛数比较,差异有统计学意义(P<0.05)。2组患者总有效率比较,差异有统计学意义(P<0.05)。2组患者总显效率比较,差异无统计学意义(P>0.05)。结论艾瑞昔布联合正清风痛宁缓释片可以有效降低类风湿关节炎患者炎症因子水平,并提高治疗有效率。

Objective To investigate the effect of imrecoxib combined with Zhengqing Fengtongning Sustained Release Tablets in the treatment of patients with rheumatoid arthritis.Methods A total of 97 patients with rheumatoid arthritis were randomly divided into experimental group(n=50)and control group(n=47).Patients in the experimental group were treated with imrecoxib and Zhengqing Fengtongning Sustained Release Tablets,while patients in the control group were treated with imrecoxib.Levels of erythrocyte sedimentation rate(ESR),C reactive protein(CRP),rheumatoid factor(RF),the number of swelling joints,Visual Analogue Scale(VAS)score of pain,the total effective rate and total apparent efficiency rate were compared between the two groups before and after treatment.Results After treatment,the ESR,CRP and rheumatoid factor levels of the both groups were significantly lower than those before treatment,and the ESR level of the experimental group was significantly lower than that of the control group(P<0.05).After treatment,the number of swelling joint showed significant difference between the two groups(P<0.05).There was a significant difference in the total effective rate between the two groups(P<0.05).There was no significant difference in total apparent efficiency rate between the two groups(P>0.05).Conclusion Imrecoxib combined with Zhengqing Fengtongning Sustained Release Tablets can effectively reduce the level of inflammatory factors and improve the efficiency of treatment in patients with rheumatoid arthritis.