糖尿病并发高血压患者血清Cys C与P物质水平之间的关系研究

Relationship between Serum Cys C and Substance P Levels in Patients with Diabetes Mellitus Complicated with Hypertension

目的探讨糖尿病并发高血压患者外周血胱抑素-C(Cys C)和P物质(substance P,SP)之间的关系。方法将糖尿病患者按照是否发生高血压分为单纯糖尿病组(A组)与并发高血压组(B组),同时选取正常对照者作为C组。比较三组人群的病历资料与外周血Cys C和SP等实验室指标,并进行相关的统计学分析。结果 A组与B组患者的平均HbAlc水平、平均SP水平与平均Cys C水平均高于C组,差异均有统计学意义。进一步进行snk-t检验可见,A组平均病程长于B组患者(t=-8.753,P <0.000 1),平均HbAlc(t=-2.355,P=0.021),平均SP水平(t=-6.164,P <0.0001)与平均Cys C水平(t=-3.185,P=0.002)均低于B组患者,差异有统计学意义。糖尿病患者高血压水平与SP水平及Cys C水平显著相关,但关系不密切(r=0.369,0.412,P<0.5),高血压患者SP水平与Cys C水平之间关系密切(r=0.526,P> 0.5),糖尿病患者高血压严重水平与病程、HbAlc,SP,CysC相关。结论糖尿病并发高血压患者外周血中Cys C和SP会升高,且这种升高与高血压的程度正相关。

Objective To investigate the relationship between Cys C and substance P(SP) in peripheral blood of patients with diabetes mellitus and hypertension. Methods Diabetic patients were divided into simple diabetes group A and hypertension group B according to whether they had hypertension or not. Meanwhile, normal controls were selected as group C. The medical records of the three groups were compared with the laboratory indexes such as Cys C and SP in peripheral blood, and relevant statistical analysis was carried out. Analysis was carried out. Results The average HbAlc, SP and Cys C levels of group A and group B were higher than those of group C(control group). Further snk-t test showed that the average course of disease in group A was longer than that in group B(t=-8.753, P< 0.000 1), the average HbAlc(t=-2.355, P=0.021), the average SP level(t=-6.164, P< 0.000 1) and the average Cys C level(t=-3.185, P= 0.002) were lower than those in group B.The difference was statistically significant. The level of hypertension in diabetic patients was significantly correlated with the level of SP and Cys C, but not closely(r=0.369,0.412,P < 0.5). There was a close relationship between the level of SP and Cys C in hypertensive patients(r=0.526,P > 0.5). The severity of hypertension in diabetic patients was correlated with the course of disease, HbAlc, SP and Cys C. Conclusion Substances Cys C and SP in the peripheral blood of diabetic patients with hypertension will increase, and this increase is positively related to the degree of hypertension.