义务献血者固定捐献单采血小板对外周血血细胞检测部分参数的影响

Effect of Fixed Platelet Donation on Some Parameters of Peripheral Blood Routine of Blood Donors

目的探讨固定捐献单采血小板对献血者外周血血细胞检测部分参数的影响。方法选择2018年6月~2019年9月期间,献血间隔期大于2周,累计捐献单采血小板20次及以上的固定献血者20例作为观察组;选择同期无既往献血史,首次捐献单采血小板的献血者20例作为对照组,分别在献血前抽取静脉血3ml,应用全自动血细胞分析仪对各献血者的白细胞计数(WBC)、红细胞计数(RBC)、血红蛋白含量(Hb)、红细胞比容(HCT)、淋巴细胞百分比(LYM%)、红细胞分布宽度(RDW)、网织红细胞百分率(RET%)、网织红细胞绝对值计数(RET#)、血小板计数(PLT)、血小板分布宽度(PDW)、血小板平均体积(MPV)和大血小板比率(P-LCR)等各项参数进行检测,并用GraphPad Prism 6.0软件对数据进行统计和分析。结果固定捐献单采血小板献血者外周血WBC,HCT,RDW,PDW,MPV,RBC,Hb,RET#,LYM%,PLT,P-LCR和RET%等参数均在正常参考值范围,与对照组相比,差异均无统计学意义(t=0.15~2.07,均P> 0.05)。结论按规定献血间隔捐献单采血小板的献血者,由于机体自身及骨髓造血的代偿调节作用,其外周血血细胞检测大部分参数均无明显变化,对机体并无明显不利影响。

Objective To explore the changes of partial parameters of blood routine test in peripheral blood for the regular apheresis platelet donors. Methods 20 donors who donated apheresis platelet more than 20 times from June 2018 to September 2019, with a blood donation interval of more than 2 weeks were selected as objects. And 20 voluntary unpaid blood donors who had no blood donation history and donated platelets for the first time were randomly selected as the control group. Before blood donation,3 ml venous blood of the donors was extracted, then the blood routine parameters such as WBC, RBC, Hb, HCT、LYM%, RDW, RET%, PLT, P-LCR, RET#, PDW and MPVwere measured by automatic blood cell analyzer, and GraphPad Prism 6.0 software was used for statistics and analysis of the data. Results The levels of WBC, HCT, RDW, RBC, Hb, LYM%, PLT, RET#, P-LCR, RET%, PDW and MPV of the regular blood donors had no statistical significance compared with control group(t =0.15~2.071,all P > 0.05).Conclusion Due to the compensatory regulation role of the body, blood donors who donate platelets at prescribed blood donation intervals have no significant changes in most parameters of peripheral blood routine, which has no significant adverse effects on the body.