广泛性焦虑症情绪脑机制研究进展

Research Progress on Emotional Brain Mechanism of Generalized Anxiety Disorder

广泛性焦虑症是一种常见的焦虑症。随着磁共振成像技术的发展,近些年来对于广泛性焦虑症的脑机制研究越来越多,基于情绪相关任务的脑影像研究对于进一步了解广泛性焦虑症生理病理机制有着重要的作用。本文通过对广泛性焦虑症认知模型以及情绪脑影像研究文献的系统回顾,总结出广泛性焦虑个体异常的情绪加工和调节过程与其大脑边缘系统和前额叶区域异常的神经活动紧密相关。担忧作为广泛性焦虑症的核心症状,其与个体大脑异常的全脑信息交互相关。在今后的研究中,应结合多模态,从多角度将行为与脑成像研究相结合,为进一步探究广泛性焦虑症病理生理机制提供基础。

Generalized anxiety disorder(GAD)is one of common anxiety disorders.Affective neuroimage researches have contributed to our knowledge of brain mechanism of GAD through task-based functional magnetic resonance imaging(fMRI)analysis.In this article,the author provided an integrated review of the cognitive model and affective neuroimage literature in GAD.Studies provide evidence for the association between altered neuro activity of brain regions,including limbic and prefrontal systems,and abnormal emotion processing and regulation.Moreover,these studies indicated that the worry,as the cardinal symptom of GAD,related with the abnormal functional brain configurations of GAD individuals.In the further study,it would gain the better understand of pathomechanism of GAD through multi-model and multi-direction brain neuroimage analysis.