摘要
从聚金属氧酸盐(POMs)对β-淀粉样蛋白(Aβ)聚集的调控作用、水解及光动力治疗等方面介绍其在阿尔兹海默症(AD)治疗中的最新研究进展,为进一步研究POMs抗AD药物活性提供了参考.
Alzheimer’s disease(AD)is a progressive neurodegenerative disorder characterized by cognitive dysfunction and memory loss.Although the exact pathogenesis of AD remains unclear,recent evidences have demonstrated that the accumulation and deposition ofβ-amyloid peptide(Aβ)is a key step in AD pathogenesis.Polyoxometalates(POMs)have the merits of adjustable structures,ease of preparation,and low cost,and thus have shown promising in AD treatment.Hence,recent advances on the POMs as a novel AD metallodrug agent are summarized.
作者
马蒙蒙
曲晓刚
MA Mengmeng;QU Xiaogang(State Key Laboratory of Rare Earth Resource Utilization,Laboratory of Chemical Biology,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;College of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China)
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2020年第5期884-891,共8页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21431007,21533008)
中国科学院前沿科学项目(批准号:QYZDJ-SSW-SLH052)资助.
