3-氨基-1-金刚烷醇合成进展

Synthesis Progress of 3-amino-1-adamantane Alcohol

3-氨基-1-金刚烷醇是糖尿病治疗药物维格列汀的关键起始物料。本文对3-氨基-1-金刚烷醇的合成方法进行了综述,以期为该化工中间体的合成及工业化生产提供参考。

3-amino-1-adamantanol is a key starting material for vildagliptin,which is the treatment medicine of diabetes mellitus.In this paper,the synthesis methods of 3-amino-1-adamantane alcohol are reviewed,hoping to provide reference for the synthesis and industrial production of the chemical intermediate.