心脉隆注射液对急性冠脉综合征PCI术后心力衰竭可溶性生长刺激表达基因2蛋白的影响

Effect of Xinmailong injection on soluble growth stimulating gene 2 protein expression in patients with heart failure after PCI for acute coronary syndrome

目的探讨心脉隆注射液对急性冠脉综合征PCI术后心力衰竭患者血清可溶性生长刺激表达基因2蛋白(sST2)的影响,评估其治疗该类心力衰竭的效果。方法选择2018年2月—2019年2月就诊于沧州市人民医院及沧州中西医结合医院的急性冠脉综合征PCI术后心力衰竭患者92例,随机分为观察组和对照组各46例,对照组给予常规西医治疗,观察组在此基础上给予心脉隆注射液静滴,分别于治疗前及治疗1周后检测2组患者血清sST2、N端前体脑钠肽(NT-proBNP)及cTnI水平,心脏超声测定左室射血分数(LVEF),计算呼吸困难评分,记录不良反应发生情况。结果治疗1周后,2组患者血清sST2、NT-proBNP、cTnI水平均较治疗前显著降低(P均<0.05),且观察组均显著低于对照组(P均<0.05);2组患者LVEF及呼吸困难评分均较治疗前显著升高(P均<0.05),且观察组均显著高于对照组(P均<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论心脉隆注射液联合基础治疗方案能有效纠正急性冠脉综合征PCI术后心力衰竭,血清sST2水平能有效评估心力衰竭患者的治疗效果。

Objective It is to investigate the effect of Xinmailong injection on soluble growth stimulus-expressing gene 2 protein(sST2)in patients with heart failure after PCI for acute coronary syndrome,in order to evaluate its effectiveness in treating this type of heart failure.Methods 92 patients with heart failure after PCI for acute coronary syndrome in Cangzhou People’s Hospital and Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Hospital from February 2018 to February 2019 were randomly divided into observation group and control group,46 cases in each group.The control group was treated with conventional western medicine,and the observation group was given Xinmailong injection by intravenous drip based on the control group.The levels of serum sST2 and N-terminal pro-brain natriuretic peptide(NT-proBNP)and cTnIwere detected before treatment and after 1 week of treatment in the two groups,cardiac left ventricular ejection fraction(LVEF)was detect by ECG,dyspnea scores were calculated,and the occurrence of adverse reactions was recorded.Results After 1 week of treatment,the levels of serum sST2,NT-proBNP and cTnI were significantly lower than those before treatment in the two groups(all P<0.05),and the observation group was significantly lower than the control group(all P<0.05);the LVEF and dyspnea scores were significantly higher than thoes before treatment the two groups(both P<0.05),and the observation group was significantly higher than the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xinmailong injection combined with basic therapy can effectively correct heart failure after PCI for acute coronary syndrome.The level of serum sST2 can effectively evaluate the therapeutic effect of patients with heart failure.