大柴胡汤对痰热腑实型中风病患者短期预后的影响研究

Study on the effect of Dachaihu decoction on short-term prognosis of patients with stroke of type of phlegm-heat excess Fu-organ

目的探究大柴胡汤对痰热腑实型缺血性脑中风病患者短期预后的影响。方法选择2017年4月—2018年3月河北省沧州中西医结合医院脑病科及高新区分院脑病科收治的缺血性脑中风痰热腑实型患者80例,按随机数字表法分为2组各40例,对照组采用常规西医综合对症治疗,观察组在此基础上辅以大柴胡汤治疗,7 d为1个疗程,连用2个疗程后,对比2组近期疗效、神经功能缺损程度、血清C反应蛋白(CRP)及治疗安全性,并随访6个月,对比2组生活质量。结果观察组近期总有效率为92.5%(37/40),高于对照组的67.5%(27/40),差异有统计学意义(P<0.05)。观察组治疗后NIHSS评分、血清CRP水平均明显低于对照组(P均<0.05)。2组均未发生严重药物不良反应。随访6个月,观察组BI指数评分明显高于对照组(P<0.05)。结论对痰热腑实型缺血性脑中风患者辅以大柴胡汤治疗,能取得更为满意的近期疗效,有助于改善神经功能缺损程度,降低血清CRP水平,以减轻炎性反应对神经组织的损害,继而有助于提高患者的生活质量,且安全。

Objective It is to investigate the effect ofDachaihu decoction on short-term prognosis of patients with ischemic stroke of type of phlegm-heat excess Fu-organ.Methods 80 patients with ischemic stroke of type of phlegm-heat excess Fu-organ treated in the Department of Cerebral Diseases and Clinic Department of Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine and High-tech Zone Branch from April 2017 to March 2018 were selected and randomly divided into two groups,40 cases in each group.The control group was treated with conventional comprehensive symptomatic therapy of western medicine,and the observation group was assistantly treated with Dachaihu decoction based on the control group.7 days as a course of treatment,after 4 consecutive courses of treatment,the short-term efficacy,degree of neurological deficit,serum C-reactive protein(CRP)and treatment safety were compared between the two groups,and followed up for 6 months to compare the quality of life in the two groups.Results The total effective rate in the near future in the observation group was 92.5%(37/40),which was higher than that 67.5%(27/40)in the control group,the difference was statistically significant(P<0.05).The NIHSS scores and serum CRP level of the observation group after treatment were significantly lower than those of the control group(P<0.05).No serious adverse drug reactions occurred in either group.After 6 months of follow-up,the BI index score of the observation group was significantly higher than that of the control group(P<0.05).Conclusion The assistant treatment with Dachaihu decoction can achieve more satisfactory short-term effects in patients with stroke of type of phlegm-heat excess Fu-organ,it is helpful and safe for improving the degree of neurological deficits,reduce serum CRP level,thus to relieve the damage of nerve tissue induced by inflammation and improving the patient's quality of life.