镁合金-黄连素-生物复合涂层的研究

Study on Magnesium Alloys-Berberine Hydrochloride-Biological Composite Coatings

镁合金在可降解骨植入领域有着广泛的应用前景,但快速降解产生大量氢气引起感染等一系列生物学问题,在镁合金表面制备超声微弧氧化膜层,再用植酸/硅烷掺杂盐酸小檗碱制备复合生物涂层,改善镁合金的降解快的问题。植酸/硅烷作为对照组,不同盐酸小檗碱为实验组,利用SEM、能谱、接触角测量仪等手段研究载药涂层的结合强度、润湿性、耐腐蚀性、组成元素等涂层性能。当盐酸小檗碱浓度为4g/L时涂层平整致密,孔隙减少,润湿角最大为48.4°,模拟体液浸泡后生成大量HA,制备的复合膜层综合性能最好。镁合金UMAO-植酸/硅烷-盐酸小檗碱-生物复合涂层的耐降解性能及耐蚀性能显著提高。

Magnesium alloys have broad application prospects in the field of biodegradable bone implantation.However,a series of biological problems,such as the rapid degradation of magnesium alloys producing a large number of hydrogen and causing infection.Ultrasound micro-arc oxidation coatings were prepared on the surface of magnesium alloys,and then phytic acid/silane doped berberine hydrochloride was used to prepare composite biological coatings to improve the degradation.Phytic acid/silane was used as the control group,and different berberine hydrochloride was used as the experimental group.SEM,energy spectroscopy,and contact angle measuring instruments were used to study the bonding strength,wettability,corrosion resistance,and composition of the drug-containing coating.When the berberine hydrochloride concentration is 4g/L,the coating is flat and dense,the pores are reduced,and the wetting angle is 48.4°at maximum.A large amount of HA is generated after immersion in body fluids.The composite film prepared has the best comprehensive performance.The degradation resistance and corrosion resistance of magnesium alloy UMAO-phytic acid/silane-berberine hydrochloride-biocomposite coating are significantly improved.