摘要
目的:探讨糖尿病与低密度脂蛋白胆固醇(LDL-C)达标的冠状动脉粥样硬化性心脏病(冠心病)患者PCI术后支架内再狭窄的关系。方法:选取2012年6月至2018年12月确诊为冠心病且成功行PCI、术后1 a复查血管造影的患者368例,PCI术前查血清LDL-C均<1.8 mmol/L,其中合并糖尿病109例。以术后1 a内发生支架内再狭窄为终点事件,采用Logistic回归分析筛选再狭窄危险因素。结果:糖尿病组高血压患者比例,血清LDL-C、甘油三酯水平及支架内再狭窄发生率均高于非糖尿病组(P均<0.05)。Logistic回归分析结果显示,在调整了性别、高血压病史后,糖尿病、血清LDL-C和甘油三酯水平升高仍是LDL-C达标的冠心病患者PCI术后1 a内支架内再狭窄发生的危险因素,OR(95%CI)分别为2.752(1.644~4.609)、3.870(1.436~10.432)、3.028(1.928~4.754)。结论:糖尿病为冠心病患者PCI术后支架内再狭窄的主要危险因素,糖尿病合并冠心病患者PCI术后应加强降脂治疗。
Aim:To explore the effects of diabetes mellitus on in-stent restenosis(ISR)after percutaneous coronary intervention(PCI)of coronary artery disease(CAD)patients with standard level of low-density lipoprotein(LDL-C).Methods:The data of 368 CAD patients receiving PCI from June 2012 to December 2018 were collected,the serum LDL-C levels before PCI were all less than 1.8 mmol/L,and 109 out of them were complicated with diabetes mellitus.Angiography was reexamined to evaluate ISR 1 year after PCI.Logistic regression analysis was used to screen the influencing factor of ISR.Results:The proportion of hypertension,the serum levels of LDL-C and triglyceride,and the incidence of ISR of diabetic group were higher than those of the non-diabetic group(P<0.05).The results of Logistic regression analysis showed that diabetes mellitus,high levels of LDL-C and triglyceride were still the risk factors of ISR after adjusting the influence of gender and hypertension,and OR(95%CI)was 2.752(1.644-4.609),3.870(1.436-10.432),3.028(1.928-4.754),respectively.Conclusion:Diabetes mellitus is a main risk factor of ISR after PCI of CAD patients.The patients with diabetes mellitus and CAD should further strengthen the treatment of lipid-lowering after PCI.
作者
崔新月
靳之
韩东建
和伟伟
张义
姜庆娇
郑颖颖
上官佳红
张金盈
沈德良
CUI Xinyue;JIN Zhi;HAN Dongjian;HE Weiwei;ZHANG Yi;JIANG Qingjiao;ZHENG Yingying;SHANGGUAN Jiahong;ZHANG Jinying;SHEN Deliang(Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Henan Province′s Key Laboratory of Cardiac Injury and Repair,Zhengzhou 450052)
出处
《郑州大学学报(医学版)》
CAS
北大核心
2020年第3期297-301,共5页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省高校科技创新人才支持计划项目(19HAST1T002)
河南省卫生计生科技领军人才计划项目。