胰腺囊性瘤的预测和诊治策略

Differential diagnosis,management and surveillance of pancreatic cystic neoplasm

随着人口的老龄化,胰腺癌的发病率呈快速增长趋势,预计到2030年成为第二位的致死性肿瘤。随着影像学检查(CT/MRI)质量的提高,人群中胰腺囊性疾病的发现率也呈直线增加。胰腺囊性疾病可分为非肿瘤性囊性疾病(假性囊肿)和肿瘤性囊性疾病。非肿瘤性囊性疾病占80%,而肿瘤性囊性疾病的发病率随着年龄的增长而增加。本文将对胰腺囊性瘤的发病情况及分类、临床特征、分子标志物、良恶性鉴别、监测和处理策略,以及目前的研究现状进行归纳和讨论,并对不同专家组提出的共识意见进行分析,提出目前面临的挑战性问题及可能的研究方向。

The incidence of pancreatic cancer is increasing very fast and pancreatic cancer is predicted to be the second leading cause of cancer death by 2030.Non-neoplastic cysts account up to 80%of all pancreatic cysts,the incidence of pancreatic cystic neoplasm increases significantly with age.In this article,we mainly discussed the incidence and classification,clinical features,prediction model,molecular markers,differential diagnosis and management,surveillance,challenge and perspective of pancreatic cystic neoplasm.We discussed the guidelines from different research organizations.