急性胰腺炎发病机制研究

Pathogenesis of acute pancreatitis

急性胰腺炎(acute pancreatitis,AP)是一种复杂的炎症反应性疾病,可导致多器官损伤甚至衰竭,急性发作时死亡率高,炎症介质所致全身炎症反应是该病死亡率高的主要原因。近年来对AP发病机制的研究取得了深入性进展,同时对AP的严重程度评估及临床诊治提供了新的策略。在本文中我们对AP发病机制的最新研究进行概述。

Acute pancreatitis is a complex inflammatory responsive disease with an increasing incidence,which can lead to multiple organ damage and even failure.Systemic inflammatory response caused by inflammatory mediators is the main cause of high mortality.Recent research has made in-depth progress on the pathogenesis of acute pancreatitis,and provides a new strategy for the assessment of acute pancreatitis severity and clinical diagnosis and treatment.In this article,the latest advances of acute pancreatitis in the pathogenesis were analyzed and discussed comprehensively.