肠道微生物及其代谢产物与心力衰竭相关性研究进展

Research progress on the correlation between intestinal microorganisms and their metabolites and heart failure

人体肠道微生物是人体消化系统中所有微生物的总称。越来越多研究表明,肠道微生物的组成和多样性发生变化与心血管系统疾病密切相关。本文将讨论肠道微生物与心力衰竭之间的相关性,包括其代谢产物(短链脂肪酸、胆汁酸、三甲胺和氧化三甲胺等)在心力衰竭发病过程中的作用,并探讨如何精准干预肠道菌群,以期为心力衰竭患者治疗提供新思路。

Human intestinal microorganisms are the collective name of all microorganisms in human digestive system.More and more studies have shown that changes in the composition and diversity of intestinal microorganisms are closely related to cardiovascular diseases.This article will discuss the correlation between intestinal microorganisms and heart failure,including the role of their metabolites(short-chain fatty acids,bile acids,trimethylamine and trimethylamine oxide)in the pathogenesis of heart failure,and explore how to precisely intervene intestinal microflora in order to provide new ideas for the treatment of heart failure patients.