羟糖甘滴眼液联合rhEGF治疗白内障术后干眼症疗效

Curative effects of hydroxyglycoside eye drops combined with rhEGF on patients with dry eye after cataract surgery

探讨羟糖甘滴眼液联合重组人表皮生长因子滴眼液对白内障术后干眼症患者BUT、SIT及FL的影响。选择2016年10月至2108年9月在我院接受治疗的白内障术后眼干症患者86例进行研究。所有患者均由同一组具5年以上临床经验的医护人员进行手术,术后给予常规换药,1 d后开放点眼给予妥布霉素地塞米松滴眼液滴眼及妥布霉素地塞米松眼膏涂眼。对照组加以羟糖甘滴眼液,观察组在对照组的基础上加以重组人表皮生长因子滴眼液。对比两组患者疗效、BUT、SIT、FL、炎症因子及不良反应发生情况。观察组总有效率为93.02%,明显高于对照组的76.74%(P<0.05)。干预前两组患者BUT、SIT及FL差异均无统计学意义(P>0.05),干预后两组BUT、SIT水平均显著升高,但观察组升高幅度更大,干预后两组FL水平均显著下降,但观察组下降更为明显(P<0.05)。干预前两组患者IL-6及TNF-α水平差异均无统计学意义(P>0.05),干预后两组患者IL-6及TNF-α水平均显著下降,但观察组下降幅度更大(P<0.05)。对照组出现1例(2.33%)不良反应,观察组出现2例(4.65%)不良反应,两组不良反应发生率差异无统计学意义(P>0.05)。羟糖甘滴眼液联合重组人表皮生长因子滴眼液较单独使用羟糖甘滴眼液可显著提高白内障术后干眼症疗效,改善BUT、SIT及FL,缓解炎症反应,不增加不良反应发生率。

To investigate the effects of hydroxycarbose glycerol eye drops combined with recombinant human epidermal growth factor eye drops on BUT,SIT and FL in patients with dry eye after cataract surgery.Eighty-six patients with ocular cataract surgery who underwent cataract surgery in our hospital from October 2016 to September 2008 were enrolled.All patients were operated by the same group of medical staff with more than 5 years of clinical experience.After routine operation,the patients were given regular dressing change.After 1 day,the eye was given tobramycin dexamethasone eye drops and dexamethasone.The control group was given hydroxyglycoside eye drops,and the observation group was subjected to recombinant human epidermal growth factor eye drops on the basis of the control group.The efficacy,BUT,Sit,FL,inflammatory factors and adverse reactions of the two groups were compared.The total effective rate of the observation group was 93.02%,which was significantly higher than that of the control group(76.74%)(P<0.05).There were no significant differences in BUT,SIT and FL between the two groups before intervention(P>0.05).After the intervention,the BUT and SIT levels were significantly increased in the two groups,but the increase in the observation group was greater.The observation group was more significant(P<0.05).There were no significant differences in IL-6 and TNF-αlevels between the two groups before intervention(P>0.05).After intervention,IL-6 and TNF-αlevels decreased significantly in the two groups,but the observation group decreased more(P<0.05).There were 1(2.33%)adverse reactions in the control group and 2(4.65%)adverse reactions in the observation group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Hydroxyglycoside eye drops combined with recombinant human epidermal growth factor eye drops can significantly improve the efficacy of dry eye syndrome after cataract surgery,improve BUT,SIT and FL,relieve inflammation,and increase without reducing the effect of glucomannan eye drops alone.