弹性蛋白酶诱导的兔颈总动脉瘤模型在颅内动脉瘤介入治疗中的应用和进展

The application of elastase-induced carotid aneurysm rabbit models in interventional treatment of intracranial aneurysm and its research progress

颅内动脉瘤介入治疗中出现的新材料和新技术需要在临床应用前进行可靠性动物实验,这不仅能有效地预测和降低临床应用中不良事件发生,而且能指导和开发新材料。弹性蛋白酶诱导的兔颈总动脉瘤模型是测试介入新材料安全性和有效性的最常用模型之一。该文主要就颅内动脉瘤介入治疗历史,弹性蛋白酶诱导的兔颈总动脉瘤模型发展,该模型相较其他动物模型的优势,用于新材料临床前实验的优势,如组织病理学、自然史、形态学和血流动力学特征,该模型弱点及发展方向等作一综述。

New materials and technologies emerging in the endovascular treatment of intracranial aneurysms require reliable animal experiments before clinical application, which can not only effectively predict and reduce the occurrence of adverse events in clinical application, but also definitely guide and develop updated materials. The elastase-induced carotid aneurysm rabbit model is one of the most commonly used experimental models for testing the safety and effectiveness of newly-developed interventional materials. This paper aims to make a comprehensive review, focusing on the history of endovascular treatment of intracranial aneurysms, the development of elastase-induced carotid aneurysm model in rabbits, the superiority of this model to other animal models and its advantages in using new materials for preclinical trials, including histopathology, natural history, morphology, hemodynamic features, etc. The disadvantages of this model and its future development direction are also discussed.