Sceletium tortuosum的化学成分研究

Study on chemical constituents of Sceletium tortuosum

为研究南非传统药用植物Sceletium tortuosum的化学成分,采用溶剂法对其地上部分进行提取和萃取,通过多种柱色谱、重结晶及高效液相色谱等方法进行系统地纯化分离,利用理化性质并结合现代分析方法鉴定化合物结构。从S.tortuosum乙酸乙酯部位中分离得到11个化合物,鉴定为3′,4′-dimethoxy[1,1′-biphenyl]-4-ol(1)、N-(4-hydroxyphenethyl)isobutyramide(2)、4-乙酰苯酚(3)、吲哚-3-甲醛(4)、7-酮-豆甾醇(5)、7-酮基-β-谷甾醇(6)、loliolide(7)、3,5,6-trihydroxy-7-megastigmen-9-one(8)、去甲基丁香色原酮(9)、cyclo(L-Pro-L-Ala)(10)、N-trans-feruloyl-3-methyldopamine(11)。化合物1~11均为首次从该属植物中分离得到,其中化合物1和2为新天然产物。

To study the chemical constituents of South Africa medicinal plants Sceletium tortuosum.Compounds were isolated and purified by various column chromatography,recrystallization,and HPLC.Their structure were elucidated by physicochemical property and spectral analysis.11 compounds were isolated from the ethyl acetate fraction of S.tortuosum and identified as 3′,4′-dimethoxy[1,1′-biphenyl]-4-ol(1),N-(4-hydroxyphenethyl)isobutyramide(2),4-hydroxyacetophenone(3),1H-indole-3-carboxadehyde(4),7-keto-stigmasterol(5),7-keto-β-sitosterol(6),loliolide(7),3,5,6-trihydroxy-7-megastigmen-9-one(8),noreugenin(9),cyclo(L-Pro-L-Ala)(10),N-trans-feruloyl-3-methyldopamine(11),respectively.Compounds 1-11 were obtained from S.tortuosum for the first time,compounds 1 and 2 were new natural products,their hydrogen and carbon assignment were reported for the first time.