乳腺癌新辅助化疗后降期患者改良根治术后放射治疗的疗效分析

Radiotherapy after Modified Radical Mastectomy for Patients with Breast Cancer in Descending Stage after Neoadjuvant Chemotherapy

目的探讨新辅助化疗后降期且行改良根治术乳腺癌患者接受放射治疗的效果。方法方便选择2016年12月-2017年12月收治的86例乳腺癌患者,结合患者是否接受放射治疗,分为甲、乙两组,其中甲组给予新辅助化疗+改良根治术,乙组在甲组治疗方案基础上联合放射治疗,对比两组临床疗效。结果治疗后,乙组Ki67表达的阳性率低于该组治疗前与同期甲组(P<0.05);乙组有效率、疾病控制率依次32.56%、90.70%,高于甲组的13.95%、60.47%,差异有统计学意义(χ^2=4.365、5.264,P=0.042、0.031<0.05);随访1年,两组患者生存率,差异无统计学意义(χ^2=0.784,P=0.547>0.05),乙组WKOQOL-100评分高于甲组,差异有统计学意义(t=4.254,P=0.471<0.05)。结论乳腺癌新辅助化疗后降期患者改良根治手术给予放射治疗,疗效理想,值得推广。

Objective To discuss the effect of radiotherapy on breast cancer patients with advanced radical mastectomy after neoadjuvant chemotherapy.Methods Convenient selection of 86 patients with breast cancer admitted from December 2016 to December 2017 were divided into two groups according to whether they received radiotherapy.Group A received neoadjuvant chemotherapy plus modified radical mastectomy,and group B received combined radiotherapy on the basis of group A.The clinical effects of the two groups were compared.Results After treatment,the positive rate of Ki67 expression in group B was lower than that in group A before treatment(P<0.05);the effective rate and disease control rate of group B were 32.56%and 90.70%,which were higher than those of group A 13.95%and 60.47%,The difference was statistically significant(χ^2=4.365,5.264,P=0.042,0.031<0.05);there was no significant difference in survival rate between the two groups after 1 year of follow-up(χ^2=0.784,P=0.547>0.05),The WKOQOL-100 score of group B was higher than that of group A,and the difference was statistically significant(t=4.254,P=0.471<0.05).Conclusion Modified radical surgery for breast cancer patients in descending stage after neoadjuvant chemotherapy is effective and worthy of promotion.