丁苯酞氯化钠注射液对伴有颅内血管狭窄的进展性卒中的治疗临床研究

Clinical Study of Dl-3n-butylphthalide and Sodium Chloride Injection in the Treatment of Progressive Stroke with Intracranial Vascular Stenosis

目的研究并探讨丁苯酞氯化钠注射液对伴有颅内血管狭窄的进展性卒中的治疗疗效。方法方便选取该院2015年7月-2018年7月发病在72 h内并伴有颅内责任血管中、重度狭窄的进展性卒中患者100例。随机分成治疗组50例和对照组50例。对照组接受基础治疗,包含降脂、改善循环等,疗程为14 d。治疗组在对照组基础上加用丁苯酞氯化钠注射液治疗,2次/d,疗程14 d。将两组病例进行神经功能缺损NIHSS评分及生活能力评定BI评分。结果两组患者治疗前NIHSS评分差异无统计学意义(P>0.05);治疗组患者治疗14 d与1个月的NIHSS评分分别为(5.12±2.68)分、(2.58±2.05)分,对照组患者治疗14 d与1个月的NIHSS评分分别为(7.04±3.00)分、(4.86±2.28)分,明显可以看出来治疗组患者的NIHSS评分比对照组低,差异有统计学意义(t=-3.374、-5.261,P<0.05);两组患者治疗前BI评分差异无统计学意义(P>0.05);治疗组患者治疗14 d与1个月的BI评分分别为(77.90±15.29)分、(88.90±10.22)分,对照组患者治疗14 d与1个月的BI评分分别为(67.40±18.58)分、(81.40±12.94)分,明显可以看出来治疗组患者的BI评分比对照组高,差异有统计学意义(t=3.086、3.217,P<0.05)。结论丁苯酞氯化钠注射液明显改善伴有颅内血管中、重度狭窄的进展性卒中的神经缺损功能,降低致残率,提高生活质量。

Objective To investigate the therapeutic effect of dl-3 n-butylphthalide and sodium chloride injection on progressive stroke with intracranial vascular stenosis.To investigate the therapeutic effect of dl-3 n-butylphthalide and sodium chloride injection on progressive stroke with intracranial vascular stenosis.Methods From July 2015 to July 2018,Convenient selection of 100 patients with progressive stroke with moderate or severe stenosis of intracranial responsible vessels were selected.They were randomly divided into treatment group(50 cases)and control group(50 cases).The control group received basic treatment,including lipid-lowering and circulation improvement,for 14 d.The treatment group was treated with Butylphthalide and Sodium Chloride Injection twice a day for 14 d on the basis of the control group.The two groups of patients were assessed with NIHSS score for neurological deficits and BI score for life ability assessment.Results There was no significant difference in NIHSS score between the two groups before treatment.The NIHSS scores of the treatment group were(5.12±2.68)points and(2.58±2.05)points on the 14 d and 1 st month of treatment,respectively,while the NIHSS scores of the control group on the 14 th and 1 st month were(7.04±3.00)points and(4.86±2.28)points.It can be seen that the NIHSS score of the patients in the treatment group was lower than that in the control group,and the difference was statistically significant(t=-3.374、-5.261,P<0.05).BI score before treatment in both groups There was no difference(P>0.05).The BI scores of the patients in the treatment group were(77.90±15.29)points and(88.90±10.22)points on the 14 d and 1 st month after treatment,respectively,while the BI scores on the 14 d and 1 st month in the control group were(67.40±18.58)points and(81.40±12.94)points.It can be seen that the BI score of the patients in the treatment group was higher than that in the control group,and the difference was statistically significant(t=3.086、3.217,P<0.05).Conclusion Dl-3 n-butylphthalide and sodium chloride injection significantly improved the function of nerve defects in patients with progressive stroke complicated with mode rate and severe intracranial vascular stenosis,reduced the disability rate,and improved the quality of life.