小剂量阿司匹林治疗对妊娠期高血压疾病患者血压和心血管功能的影响

Effect of Low-dose Aspirin on Blood Pressure and Cardiovascular Function in Patients with Pregnancy-induced Hypertension

目的探究将小剂量阿司匹林治疗方案应用于妊娠期高血压疾病患者治疗中,对患者血压和心血管功能造成的影响,探究临床实际应用价值。方法该次研究中所有实验对象均为该院2016年4月-2018年12月间收入的妊娠期高血压患者,患者在入院后经统计分析资料后录入其中42例,作为该次实验的研究对象,通过随机分组法将患者进行两组均分,记录为对照组(n=21)与实验组(n=21)。对照组患者应用安慰剂进行控制,实验组患者则选择阿司匹林小剂量治疗。对比两组患者在治疗后血压、凝血以及血液流变学的指标变化分析,不良反应发生率。结果治疗完成后,实验组患者的治疗总有效率数据记录为90.48%,其实验数据对比分析高于对照组患者的57.14%,数据差异有统计学意义(χ^2=6.035, P=0.014)。实验组患者的不良反应发生率为9.52%,与对照组患者的不良反应发生率9.52%完全相同,差异无统计学意义(χ^2=0.000,P=1.000)。同时实验组患者的凝血酶原时间(12.64±0.94)s和凝血酶时间(18.14±3.06)s有明显延长,患者的血压值较对照组来说明显更低,数据对比差异有统计学意义(P<0.05)。结论在对妊娠期高血压患者进行治疗时,应用小剂量阿司匹林对患者进行治疗,有助于改善患者的心血管功能和血压值,有助于减轻患者妊娠期高血压状况,对于患者预后改善来说有积极意义,同时也不会引起患者发生其他用药不良反应,是一种安全且有效的治疗方案,值得推广使用。

Objective To explore the effect of low-dose aspirin on blood pressure and cardiovascular function in patients with pregnancy-induced hypertension, and to explore the clinical application value. Methods All the subjects in this study were patients with gestational hypertension from April 2016 to December 2018 in the hospital. After admission, 42 patients were enrolled in the statistical analysis class. As the subjects of this study, the patients were divided into two groups by random grouping method, and recorded as the control group(n=21) and the experimental group(n=21). The control group was treated with placebo, while the experimental group was treated with aspirin in low dose. The changes of blood pressure, coagulation and hemorheology were compared between the two groups after treatment, and the incidence of adverse reactions was analyzed. Results After the treatment, the total effective rate of the experimental group was 90.48%. The comparative analysis of the experimental data was higher than that of the control group(57.14%). The difference was statistically significant(χ^2=6.035, P=0.014). The incidence of adverse reactions in the experimental group was 9.52%, which was exactly the same as that in the control group. The difference was not statistically significant(χ^2=0.000,P=1.000). At the same time, prothrombin time(12.64±0.94)s and the thrombin time(18.14±3.06) s of the experimental group patients were significantly prolonged, and the blood pressure of the patients was significantly lower than that of the control group, and the data contrast was significantly different(P<0.05). Conclusion The application of low-dose aspirin in the treatment of patients with gestational hypertension is helpful to improve the cardiovascular function and blood pressure of patients, to alleviate the status of patients with gestational hypertension,to improve the prognosis of patients, and to avoid other adverse drug reactions. It is a safe and effective treatment.Therapeutic scheme is worth popularizing.