辨证穴位敷贴治疗慢性持续期儿童哮喘的临床疗效与T淋巴细胞亚群变化水平的相关性研究

Correlation between the clinical efficacy and T-lymphocyte subsets change level of acupoint application by syndrome differentiation in the treatment of chronic persistent children asthma

目的研究辨证穴位敷贴治疗慢性持续期儿童哮喘的临床疗效与T淋巴细胞亚群变化水平的相关性。方法选取2018年7月-2019年7月于该院就诊的慢性持续期哮喘患儿80例,根据随机数字表法分为两组。对照组采用西医治疗,观察组在常规西医治疗的同时加用辨证穴位敷贴。比较两组的疗效,分析观察组患儿的T淋巴细胞亚群变化情况,探讨患儿肺功能指标、儿童哮喘控制测试问卷(C-ACT)评分及哮喘发作次数与T淋巴细胞亚群变化水平的相关性。结果观察组总有效率为97.5%,对照组为80.0%,观察组疗效显著优于对照组(P<0.05)。观察组患儿治疗后CD3^+、CD4^+、CD4^+/CD8^+水平均明显提高,CD8^+水平明显降低,与治疗前比较差异有统计学意义(均P<0.05)。观察组患儿治疗后肺功能指标1秒钟用力呼气容积(FEV1)和呼气峰流速(PEF)均有显著提高,C-ACT评分显著升高,哮喘发作次数显著降低,与治疗前比较差异均有统计学意义(均P<0.05)。观察组患儿治疗后FEV1、PEF与CD3^+、CD4^+、CD4^+/CD8^+水平呈正相关(P<0.05),与CD8^+水平呈负相关(P<0.05)。观察组患儿治疗后C-ACT评分与CD3^+、CD4^+、CD4^+/CD8^+水平呈正相关(P<0.05),与CD8^+水平呈负相关(P<0.05)。观察组患儿治疗后哮喘发作次数与CD3^+、CD4^+、CD4^+/CD8^+水平呈负相关(P<0.05),与CD8^+水平呈正相关(P<0.05)。结论辨证穴位敷贴治疗慢性持续期儿童哮喘的临床疗效显著,其通过改善患儿血清T淋巴细胞亚群水平来控制临床症状和哮喘发作次数,促进患儿康复。

Objective To study the correlation between the clinical efficacy and T-lymphocyte subsets change level of acupoint application by syndrome differentiation in the treatment of chronic persistent children asthma.Methods 80 cases of chronic persistent children asthma in our hospital from July 2018 to July 2019 were selected,they were randomly divided into two groups according to the random number table,the control group was treated with Western medicine,the observation group was treated with acupoint application by syndrome differentiation on the basis of Western medicine,the efficacy of two groups compared,and the changes of T-lymphocyte subsets of children in observation group were observed,the correlation between lung function index,children asthma control test questionnaire(C-ACT)score,asthma attacks number and the changes of T-lymphocyte subsets were explored.Results The total effective rate was 97.5%of observation group and 80.0%of control group,the effect of observation group was significantly better than that of control group(P<0.05).The levels of CD3^+,CD4^+,CD4^+/CD8^+in total in observation group after treatment were significantly higher than before treatment,and the CD8^+levels were significantly lower than before treatment(P<0.05).The lung function indexes of FEV1 and PEF were significantly increased in observation group,and the C-ACT score and asthma attacks number were significantly lower than before treatment(P<0.05).The pulmonary function indexes FEV1 and PEF in observation group after treatment were positively correlated with CD3^+,CD4^+,CD4^+/CD8^+levels(P<0.05),and negatively correlated with CD8^+levels(P<0.05).The C-ACT score in observation group after treatment were positively correlated with CD3^+,CD4^+,CD4^+/CD8^+levels(P<0.05),and negatively correlated with CD8^+levels(P<0.05).The asthma attacks number in observation group after treatment were negatively correlated with CD3^+,CD4^+,CD4^+/CD8^+levels(P<0.05),and positively correlated with CD8^+levels(P<0.05).Conclusion Acupoint application by syndrome differentiation in the treatment of chronic persistent children asthma has significant clinical efficacy,it improves the clinical symptoms and asthma attacks number by improving the T-lymphocyte subsets level in children,and promotes the rehabilitation of children.