中西医结合治疗肺尘埃沉着病合并慢性阻塞性肺疾病患者的疗效

Curative Effects of Integrative Traditional Chinese and Western Medicine on Patients with Pneumoconiosis Complicated with Chronic Obstructive Pulmonary Disease

目的探讨噻托溴铵联合黄根片治疗肺尘埃沉着病合并慢性阻塞性肺疾病患者的临床疗效。方法选取2017年12月至2019年2月郴州市疾病预防控制中心收治的肺尘埃沉着病合并慢性阻塞性肺疾病患者157例为观察组,选取同期郴州市疾病预防控制中心收治的肺尘埃沉着病合并慢性阻塞性肺疾病患者143例为对照组。两组均予以吸氧、止咳祛痰平喘、肺灌洗、预防感染、康复训练等常规对症治疗。对照组患者吸入噻托溴铵粉雾剂,观察组在对照组基础上口服黄根片。比较治疗前后两组中医临床症状积分、肺功能、生命质量评分及血清白细胞介素(IL-1)、肿瘤坏死因子-α(TNF-α)水平。结果治疗前,两组中医临床症状积分、用力肺活量(FVC)、第一秒钟用力呼气容积(FEV1)、每分钟最大通气量(MVV)、生命质量评分及血清IL-1、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,两组FVC、FEV1及MVV高于治疗前(P<0.05),且观察组高于对照组(P<0.05);治疗后,两组各中医临床症状积分,症状、活动受限、疾病影响评分及生命质量总评分,血清IL-1、TNF-α水平低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论噻托溴铵联合黄根片治疗肺尘埃沉着病合并慢性阻塞性肺疾病患者可改善其临床症状与肺功能,提高生命质量。

Objective To observe the clinical efficacy of tiotropium bromide combined with Huanggen tablet in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease.Methods A total of 157 patients with pneumoconiosis combined with chronic obstructive pulmonary disease admitted to Chenzhou Disease Prevention and Control Center of Occupational Disease from December 2017 to February 2019 were selected as the observation group,and 143 patients with pneumoconiosis and chronic obstructive pulmonary disease admitted to Chenzhou Disease Prevention and Control Center of Occupational Disease during the same period were selected as the control group.Both groups were given routine symptomatic treatments such as oxygen inhalation,cough,expectoration and asthma relief,lung lavage,infection prevention,rehabilitation training and so on.Patients in the control group inhaled tiotropium bromide powder and in the observation group was given Huanggen tablet.The scores of clinical symptoms,pulmonary function,quality of life and serum levels of IL-1 and TNF-alpha were compared between the 2 groups before and after treatment.Results Before treatment,there was no significant difference in the scores of clinical symptoms,FVC,FEV1%,MVV,quality of life and serum IL-1,TNF-alpha levels between the 2 groups and the difference was not statistically significant(P>0.05);after treatment,FVC,FEV1 and MVV in the 2 groups were higher than those before treatment(P<0.05),and the observation group was higher than the control group(P<0.05);after treatment,tthe scores of clinical symptoms,symptoms,activity limitation,disease effect scores and quality of life scores of the 2 groups,and the levels of IL-1 and TNF-αin serum were lower than those before treatment(P<.05),and those in the observation group were lower than those in the control group(P<0.05).Conclusion Tiotropium bromide combined with Huanggen tablets in the treatment of pneumoconiosis combined with chronic obstructive pulmonary disease can improve the clinical symptoms and lung function and the quality of life.