儿童亚临床甲状腺功能减退与心血管疾病的研究进展

Research progress on the correlation between subclinical hypothyroidism and cardiovascular disease in childhood

亚临床甲状腺功能减退症(SH)是一种常见的内分泌疾病,它以实验室检查中血清总或游离的甲状腺激素正常而促甲状腺激素(TSH)升高为特点。随着SH发病率的逐年升高,TSH的甲状腺以外的作用日益受到人们关注。越来越多的研究显示成人SH患者常伴有心血管疾病发生风险的增高,却忽视了SH是否会对儿童健康结局造成影响。尽管目前的研究结果不足以推荐所有轻度无症状SH患儿使用左旋甲状腺素(L-T4)治疗,但强调有必要评估这种情况下患儿的心血管疾病风险程度。

Subclinical hypothyroidism( SH) is a category of disease based on laboratory tests,which total or free thyroid hormone is in the normal range,and thyroid-stimulating hormone( TSH) is mild or moderate above normal range disease. With the increasing incidence of subclinical hypothyroidism,the extrathyroidal effect of TSH has got more and more attention. Many studies have shown that adult who suffered SH are often associated with an increased risk of cardiovascular disease,but ignore what contribute to children’s health outcomes. However,the problem whether subclinical hypothyroidism would cause adverse health outcomes in children still remains controversial.