调节性T细胞在子痫前期中的研究进展

Research progress of regulatory T cells in preeclampsia

子痫前期(PE)是妊娠期特有的疾病,迄今为止,尽管进行了广泛研究,子痫前期病因和发病机制尚未完全阐明,越来越多证据显示子痫前期患者存在炎症免疫反应过度激活现象,母体对胎儿的免疫排斥是其原因之一,调节性T细胞和效应性T细胞的不平衡可能是导致排斥的原因。调节性T细胞(Treg)在维持自身免疫耐受,生理性免疫应答以及介导母体对胎儿的耐受中起着至关重要的作用。Tregs细胞在免疫学研究是当前研究的热点。本文就调节性T细胞在子痫前期发生发展间的关系做一综述。

Preeclampsia(PE)is characterized by hypertension and proteinuria.Despite extensive research,the etiology and pathogenesis of PE are not completely understood.Increasing evidence suggests that an exaggerated maternal systemic inflammatofrery response may play a central role in the pathogenesis of preeclampsia(PE).Regulatory T cells(Tregs)are a specialized subpopulation of T cells that act as potent suppressors of inflammation to prevent autoimmunity and graft rejection.A reduction in maternal Treg populations could prevent immunological tolerance of the fetus and has been associated with obstetrical complications,such as miscarriage,PE.The research of Treg in immunology is the focus of current research.In this paper,the relationship between the occurrence and development of regulatory Treg in preeclampsia is reviewed.